Ultrasound-assisted extraction of phillyrin from Forsythia suspensa

► Ultrasonic wave accelerates the extraction of phillyrin. ► Ultrasonic wave efficiently improves the extraction efficiency of phillyrin. ► The results are helpful for the full utilization of Forsythia suspense. ► The ultrasound-assisted extraction is a powerful tool for the extraction of phytochemi...

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Bibliographic Details
Published in:Ultrasonics sonochemistry 2011-03, Vol.18 (2), p.549-552
Main Authors: Xia, En-Qin, Ai, Xu-Xia, Zang, Sheng-Ye, Guan, Ting-Ting, Xu, Xiang-Rong, Li, Hua-Bin
Format: Article
Language:English
Subjects:
Biomarkers - analysis
Chemical Fractionation - methods
Chemistry
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal - chemistry
Exact sciences and technology
Extraction
Forsythia - chemistry
Forsythia suspensa
General and physical chemistry
Glucosides - analysis
Glucosides - isolation & purification
Phillyrin
Physical chemistry of induced reactions (with radiations, particles and ultrasonics)
Solvents - chemistry
Sonication
Temperature
Time Factors
Ultrasonic chemistry
Ultrasound
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Summary:► Ultrasonic wave accelerates the extraction of phillyrin. ► Ultrasonic wave efficiently improves the extraction efficiency of phillyrin. ► The results are helpful for the full utilization of Forsythia suspense. ► The ultrasound-assisted extraction is a powerful tool for the extraction of phytochemicals. Forsythia suspensa (Thunb.) Vahl is one of the most widely used traditional Chinese medicines, and possesses important biological activities, such as antibacterial, antiviral, anti-inflammatory and antioxidant activities. Phillyrin is the main bioactive component of Forsythia suspensa. In this paper, ultrasound-assisted extraction of phillyrin from Forsythia suspensa was studied with HPLC-photodiode array detection. Effects of several experimental parameters, such as type and concentration of extracting solvent, ratio of liquid to material, extraction temperature, and time of sonication on extraction efficiencies of phillyrin from Forsythia suspensa were evaluated. The optimal extraction conditions were 1 g plant sample with 10 ml of 20% methanol and the extraction for 60 min at 60 °C under ultrasonic irradiation. Under the optimum conditions, the yield of phillyrin was 0.713 ± 0.009 mg/g. The results indicated that the ultrasound-assisted extraction is a very useful method for the extraction of important phytochemicals from plant materials.
ISSN:1350-4177
1873-2828
DOI:10.1016/j.ultsonch.2010.09.015