Reticulocyte HL-A Antigens

THE HL-A system of leucocyte antigens and the ABH red cell groups are believed to be important histocompatibility factors in man 1 and can be detected on leucocytes, platelets and most other tissues 2 . Although A 1 and B antigens have been demonstrated on leucocytes, attempts to detect HL-A specifi...

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Bibliographic Details
Published in:Nature (London) 1969-03, Vol.221 (5185), p.1062-1063
Main Authors: HARRIS, R, ZERVAS, J. D
Format: Article
Language:English
Subjects:
Anemia, Hemolytic, Autoimmune - immunology
Antigen-Antibody Reactions
Antigens
Erythrocytes - immunology
Histocompatibility
Humanities and Social Sciences
Humans
letter
Leukocytes - immunology
multidisciplinary
Polycythemia Vera - immunology
Reticulocytes - immunology
Science
Science (multidisciplinary)
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Summary:THE HL-A system of leucocyte antigens and the ABH red cell groups are believed to be important histocompatibility factors in man 1 and can be detected on leucocytes, platelets and most other tissues 2 . Although A 1 and B antigens have been demonstrated on leucocytes, attempts to detect HL-A specificities on red cells have so far failed 3 . The apparent absence of HL-A from human red cells is unlike the situation found in the mouse where H-2 antigens, the homologues of HL-A, can usually be demonstrated on red cells 4 . It is logical that human red cell precursors should possess HL-A antigens and we have therefore investigated reticulocytes by absorption studies, which does not seem to have been done before (van Rood, personal communication).
ISSN:0028-0836
1476-4687
DOI:10.1038/2211062a0