Exaggerated Vascular Response Due to Endothelial Dysfunction and Role of the Renin-Angiotensin System at Early Stage of Renal Hypertension in Rats

We investigated whether endothelial dysfunction might contribute to the exaggerated vasoconstriction that was induced by the administration of norepinephrine at the early stage of one-kidney, one-clip renal hypertension (1K1C) in rats. We also studied the role of the renin-angiotensin system in this...

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Bibliographic Details
Published in:Circulation research 1994-01, Vol.74 (1), p.130-138
Main Authors: Hoshino, Jin, Sakamaki, Tetsuo, Nakamura, Tetsuya, Kobayashi, Masato, Kato, Misa, Sakamoto, Hironosuke, Kurashina, Toshiaki, Yagi, Atsuko, Sato, Kunio, Ono, Zenpei
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Vessels - drug effects
Blood Vessels - physiopathology
Cardiology. Vascular system
Endothelium, Vascular - physiopathology
Experimental diseases
Hypertension, Renal - physiopathology
Male
Medical sciences
Nicardipine - pharmacology
Norepinephrine - pharmacology
Rats
Rats, Wistar
Reference Values
Renin-Angiotensin System - physiology
Vasoconstriction - drug effects
Vasodilation
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Summary:We investigated whether endothelial dysfunction might contribute to the exaggerated vasoconstriction that was induced by the administration of norepinephrine at the early stage of one-kidney, one-clip renal hypertension (1K1C) in rats. We also studied the role of the renin-angiotensin system in this phenomenon. Male Wistar rats were killed 48 hours after the induction of renal artery stenosis or sham operation, and ring preparations of the thoracic aorta were obtained. The isometric contraction and relaxation of aortic strips produced by norepinephrine and acetylcholine, respectively, were recorded with a force-displacement transducer. The aorta of 1K1C rats showed a significantly (P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.74.1.130