HLA class I/class II interaction in early onset pauciarticular juvenile chronic arthritis

• Published in: Immunogenetics (New York) 1994, Vol.39 (1), p.61-64
• Main Authors: PAUL, C, HAAS, J. P, ALBERT, E. D, SCHOENWALD, U, TRUCKENBRODT, H, BETTINOTTI, M. P, BÖNISCH, J, BRÜNNLER, G, KELLER, E, NEVINNY-STICKEL, C, ZHU YAO
• Format: Article
• Language: English
• Subjects: Alleles; Arthritis, Juvenile - immunology; Base Sequence; Biological and medical sciences; Diseases of the osteoarticular system; DNA Primers - chemistry; Genetic Markers; Genetic Predisposition to Disease; Histocompatibility Antigens Class II - genetics; HLA-A2 Antigen - genetics; HLA-DP Antigens - genetics; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; Humans; Inflammatory joint diseases; Medical sciences; Molecular Sequence Data; Polymerase Chain Reaction
• ISSN: 0093-7711; 1432-1211
• DOI: 10.1007/BF00171799

The most homogeneous form of juvenile chronic arthritis (JCA), early onset pauciarticular juvenile chronic arthritis (EOPA-JCA), is simultaneously associated with a series of major histocompatibility complex (MHC) class I (HLA-A2) and MHC class II (DR5/8/6-DR/DQ) haplotypes and (DPB1*0201) alleles, resulting in a complex pattern of associations. It is generally accepted that there is no linkage disequilibrium for all combinations of HLA-A2, DR5/8/6-DR/DQ haplotypes, and DPB1*0201. Thus, these associations are considered to be independent of each other. There is strong evidence for HLA-DP/DR-DQ interaction in EOPA-JCA patients. Interaction between different disease-associated HLA alleles could be a general phenomenon and could possibly provide insight into a molecular mechanism of the multiple associations. We investigated by DNA typing a large homogeneous group of EOPA-JCA patients for a possible interaction between HLA-A2 and HLA class II markers.