Renal Artery Stenosis and Ischemia: Effect on Renal Blood Flow and Extraction Fraction

The clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine provide a measure of effective renal plasma flow, yet these clearances are proportional to renal plasma flow only if the extraction fraction remains constant. To determine the effect of unilateral renal artery stenosis, captopri...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-01, Vol.23 (1), p.96-103
Main Authors: Taylor, Andrew, Eshima, Dennis
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Captopril - pharmacology
Glomerular Filtration Rate
Iodohippuric Acid - pharmacokinetics
Ischemia - physiopathology
Kidney - blood supply
Kidney - metabolism
Male
Medical sciences
Metabolic Clearance Rate
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Rats
Rats, Sprague-Dawley
Renal Artery Obstruction - physiopathology
Renal Circulation
Renovascular diseases
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Summary:The clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine provide a measure of effective renal plasma flow, yet these clearances are proportional to renal plasma flow only if the extraction fraction remains constant. To determine the effect of unilateral renal artery stenosis, captopril, renal ischemia, and partial renal vein occlusion on renal blood flow and the extraction fraction of [I]orthoiodohippurate, Tc-mercaptoacetyltriglycine, and [I]iothalamate, we conducted a series of constant infusion studies in Sprague-Dawley rats. Renal artery flow reduction of approximately 70% decreased the extraction fraction of all three agents (P≤.05). Captopril had no effect on extraction fraction in controls, but it produced a further decrease in extraction fraction of Tc-mercaptoacetyltriglycine and [I]orthoiodohippurate in rats with renal artery stenosis (P≤.05). Ischemia resulted in a 16% decrease in flow (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.23.1.96