Renal Artery Stenosis and Ischemia: Effect on Renal Blood Flow and Extraction Fraction

The clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine provide a measure of effective renal plasma flow, yet these clearances are proportional to renal plasma flow only if the extraction fraction remains constant. To determine the effect of unilateral renal artery stenosis, captopri...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-01, Vol.23 (1), p.96-103
Main Authors: Taylor, Andrew, Eshima, Dennis
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Captopril - pharmacology
Glomerular Filtration Rate
Iodohippuric Acid - pharmacokinetics
Ischemia - physiopathology
Kidney - blood supply
Kidney - metabolism
Male
Medical sciences
Metabolic Clearance Rate
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Rats
Rats, Sprague-Dawley
Renal Artery Obstruction - physiopathology
Renal Circulation
Renovascular diseases
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Eshima, Dennis
description The clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine provide a measure of effective renal plasma flow, yet these clearances are proportional to renal plasma flow only if the extraction fraction remains constant. To determine the effect of unilateral renal artery stenosis, captopril, renal ischemia, and partial renal vein occlusion on renal blood flow and the extraction fraction of [I]orthoiodohippurate, Tc-mercaptoacetyltriglycine, and [I]iothalamate, we conducted a series of constant infusion studies in Sprague-Dawley rats. Renal artery flow reduction of approximately 70% decreased the extraction fraction of all three agents (P≤.05). Captopril had no effect on extraction fraction in controls, but it produced a further decrease in extraction fraction of Tc-mercaptoacetyltriglycine and [I]orthoiodohippurate in rats with renal artery stenosis (P≤.05). Ischemia resulted in a 16% decrease in flow (P
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To determine the effect of unilateral renal artery stenosis, captopril, renal ischemia, and partial renal vein occlusion on renal blood flow and the extraction fraction of [I]orthoiodohippurate, Tc-mercaptoacetyltriglycine, and [I]iothalamate, we conducted a series of constant infusion studies in Sprague-Dawley rats. Renal artery flow reduction of approximately 70% decreased the extraction fraction of all three agents (P≤.05). Captopril had no effect on extraction fraction in controls, but it produced a further decrease in extraction fraction of Tc-mercaptoacetyltriglycine and [I]orthoiodohippurate in rats with renal artery stenosis (P≤.05). Ischemia resulted in a 16% decrease in flow (P&lt;.01) but a much larger (47% to 65%) decrease in extraction fraction of all three agents (P&lt;.002). Partial renal vein occlusion also decreased the extraction fraction of all three agents (P≤.05). The changes in extraction fraction imply that the clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine in disease states may not be proportional to renal plasma flow. Furthermore, in rats with renal artery stenosis it appears that renal blood flow must fall below a critical threshold of approximately 58% before extraction fraction decreases; as renal blood flow is further reduced below this threshold, there is a corresponding reduction in extraction fraction (P&lt;.01).</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.23.1.96</identifier><identifier>PMID: 8282336</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Biological and medical sciences ; Captopril - pharmacology ; Glomerular Filtration Rate ; Iodohippuric Acid - pharmacokinetics ; Ischemia - physiopathology ; Kidney - blood supply ; Kidney - metabolism ; Male ; Medical sciences ; Metabolic Clearance Rate ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Rats ; Rats, Sprague-Dawley ; Renal Artery Obstruction - physiopathology ; Renal Circulation ; Renovascular diseases</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1994-01, Vol.23 (1), p.96-103</ispartof><rights>1994 American Heart Association, Inc.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. 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To determine the effect of unilateral renal artery stenosis, captopril, renal ischemia, and partial renal vein occlusion on renal blood flow and the extraction fraction of [I]orthoiodohippurate, Tc-mercaptoacetyltriglycine, and [I]iothalamate, we conducted a series of constant infusion studies in Sprague-Dawley rats. Renal artery flow reduction of approximately 70% decreased the extraction fraction of all three agents (P≤.05). Captopril had no effect on extraction fraction in controls, but it produced a further decrease in extraction fraction of Tc-mercaptoacetyltriglycine and [I]orthoiodohippurate in rats with renal artery stenosis (P≤.05). Ischemia resulted in a 16% decrease in flow (P&lt;.01) but a much larger (47% to 65%) decrease in extraction fraction of all three agents (P&lt;.002). Partial renal vein occlusion also decreased the extraction fraction of all three agents (P≤.05). The changes in extraction fraction imply that the clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine in disease states may not be proportional to renal plasma flow. Furthermore, in rats with renal artery stenosis it appears that renal blood flow must fall below a critical threshold of approximately 58% before extraction fraction decreases; as renal blood flow is further reduced below this threshold, there is a corresponding reduction in extraction fraction (P&lt;.01).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Captopril - pharmacology</subject><subject>Glomerular Filtration Rate</subject><subject>Iodohippuric Acid - pharmacokinetics</subject><subject>Ischemia - physiopathology</subject><subject>Kidney - blood supply</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal Artery Obstruction - physiopathology</subject><subject>Renal Circulation</subject><subject>Renovascular diseases</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpdkc1r3DAQxUVpSLdprr0VTCm92Z2RZMnKLQ27SSDQ0o_QnoRWllknWiuVbLb576NkTQ45iNHwfhrePBHyHqFCFPgFsLr4-72irMJKiVdkgTXlJa8Fe00WgIqXCvHPG_I2pRsA5JzLQ3LY0IYyJhbk-ocbjC9O4-jiffFzdENIfSrM0BaXyW7ctjcnxbLrnB2LMBR7-qsPoS1WPuyewOX_MRo79llfzZd35KAzPrnjuR6R36vlr7OL8urb-eXZ6VVpucS6pMKgcK2y0lBaS9W6NefWsg5QgForSzuurAFwLZNUSQlg6rWSrWp4Z5lhR-Tzfu5dDP8ml0a97ZN13pvBhSlpKRgDIVQGP74Ab8IU8zJJU6ipaAAgQ9UesjGkFF2n72K_NfFeI-jHtDWgzmlryjRqJfKDD_PUab117TM-x5v1T7NukjW-i2awfXrGWKMwe8sY32O74PM_pFs_7VzUG2f8uNHZGfDssESlOGDuynywZg8O0JUB</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Taylor, Andrew</creator><creator>Eshima, Dennis</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199401</creationdate><title>Renal Artery Stenosis and Ischemia: Effect on Renal Blood Flow and Extraction Fraction</title><author>Taylor, Andrew ; Eshima, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4715-26a16ed9c7a22579deb44cc3f01609b9c2f49ca00ed37297700a5b97d984fc3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Captopril - pharmacology</topic><topic>Glomerular Filtration Rate</topic><topic>Iodohippuric Acid - pharmacokinetics</topic><topic>Ischemia - physiopathology</topic><topic>Kidney - blood supply</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Renal Artery Obstruction - physiopathology</topic><topic>Renal Circulation</topic><topic>Renovascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, Andrew</creatorcontrib><creatorcontrib>Eshima, Dennis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, Andrew</au><au>Eshima, Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Artery Stenosis and Ischemia: Effect on Renal Blood Flow and Extraction Fraction</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1994-01</date><risdate>1994</risdate><volume>23</volume><issue>1</issue><spage>96</spage><epage>103</epage><pages>96-103</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>The clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine provide a measure of effective renal plasma flow, yet these clearances are proportional to renal plasma flow only if the extraction fraction remains constant. To determine the effect of unilateral renal artery stenosis, captopril, renal ischemia, and partial renal vein occlusion on renal blood flow and the extraction fraction of [I]orthoiodohippurate, Tc-mercaptoacetyltriglycine, and [I]iothalamate, we conducted a series of constant infusion studies in Sprague-Dawley rats. Renal artery flow reduction of approximately 70% decreased the extraction fraction of all three agents (P≤.05). Captopril had no effect on extraction fraction in controls, but it produced a further decrease in extraction fraction of Tc-mercaptoacetyltriglycine and [I]orthoiodohippurate in rats with renal artery stenosis (P≤.05). Ischemia resulted in a 16% decrease in flow (P&lt;.01) but a much larger (47% to 65%) decrease in extraction fraction of all three agents (P&lt;.002). Partial renal vein occlusion also decreased the extraction fraction of all three agents (P≤.05). The changes in extraction fraction imply that the clearances of [I]orthoiodohippurate and Tc-mercaptoacetyltriglycine in disease states may not be proportional to renal plasma flow. Furthermore, in rats with renal artery stenosis it appears that renal blood flow must fall below a critical threshold of approximately 58% before extraction fraction decreases; as renal blood flow is further reduced below this threshold, there is a corresponding reduction in extraction fraction (P&lt;.01).</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>8282336</pmid><doi>10.1161/01.HYP.23.1.96</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source Free E-Journal (出版社公開部分のみ）
subjects Animals
Biological and medical sciences
Captopril - pharmacology
Glomerular Filtration Rate
Iodohippuric Acid - pharmacokinetics
Ischemia - physiopathology
Kidney - blood supply
Kidney - metabolism
Male
Medical sciences
Metabolic Clearance Rate
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Rats
Rats, Sprague-Dawley
Renal Artery Obstruction - physiopathology
Renal Circulation
Renovascular diseases
title Renal Artery Stenosis and Ischemia: Effect on Renal Blood Flow and Extraction Fraction
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