Anti-Colony-Stimulating Factor-1 Antibody Staining in Primary Breast Adenocarcinomas Correlates With Marked Inflammatory Cell Infiltrates and Prognosis

Background:Clinical studies have shown that a marked lymphoplasmocytic reaction in breast tumors is findings raise the possibility that an inflammatory cell reaction might be a tumor-induced response that tends to promot tumor growth. Purpose: We assessed the expression of colony-stimulating factor-...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1994-01, Vol.86 (2), p.120-126
Main Authors: Scholl, S. M., Pallud, C., Beuvon, F., Hacene, K., Stanley, E. R., Rohrschneider, L., Tang, R., Pouillart, P., Lidereau, R.
Format: Article
Language:English
Subjects:
Adenocarcinoma - immunology
Adenocarcinoma - pathology
Adenocarcinoma - ultrastructure
Biological and medical sciences
Breast cancer
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Breast Neoplasms - ultrastructure
Cell Nucleus - immunology
Female
Gynecology. Andrology. Obstetrics
Humans
Immunity (Disease)
Immunohistochemistry
Immunophenotyping
In Situ Hybridization
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - physiology
Macrophage Colony-Stimulating Factor - immunology
Macrophage Colony-Stimulating Factor - physiology
Mammary gland diseases
Medical research
Medical sciences
Middle Aged
Neoplasm Invasiveness
Prognosis
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background:Clinical studies have shown that a marked lymphoplasmocytic reaction in breast tumors is findings raise the possibility that an inflammatory cell reaction might be a tumor-induced response that tends to promot tumor growth. Purpose: We assessed the expression of colony-stimulating factor-1 (CSF-) as well as the prevalence of specific tumor-infiltrating lymphocytes and monocytes in breast tumors. Methods: Tissue sections were obtained from archival paraffin blocks from 196 breast cancer patients. Seventy-eight percent of the women had beren treated by mastectomy and 22% by lumpectomy. Median age of the patients was 54 years, and median follow-up was 7.3 years. Immuno-histochemical and in situ hybridization techniques were used to characterize the specimens. Results: Markedly high numbers of CD45RO-positive T- and L26-positive B-cell infiltrates were found in 13% and 17% of the tissue specimens, respectively. CSF-1 receptor-posittive monocytes were detected in 48% and CD68-poistive monocytes in 90% of the tumors. In turn, tumors with large fractions of CD68-positive monocytes also showed CSF-1 receptor-positive monocytes (P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/86.2.120