Congenital deficiency of factor VII in subarachnoid hemorrhage

Factor VII is essential for coagulation activation by the extrinsic pathway. Hemorrhages of the central nervous system in patients with congenital factor VII deficiency seem to have a higher incidence compared with other congenital coagulopathies. The purpose of this paper is to report two rare case...

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Bibliographic Details
Published in:Stroke (1970) 1994-02, Vol.25 (2), p.508-510
Main Authors: PAPA, M. L, SCHISANO, G, FRANCO, A, NINA, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Bleeding Time
Blood Coagulation
Blood Coagulation Factors - analysis
Factor VII - analysis
Factor VII Deficiency - blood
Factor VII Deficiency - complications
Female
Fibrinogen - analysis
Humans
Male
Medical sciences
Neurology
Partial Thromboplastin Time
Pedigree
Platelet Count
Prothrombin Time
Reference Values
Subarachnoid Hemorrhage - blood
Subarachnoid Hemorrhage - complications
Thrombin Time
Vascular diseases and vascular malformations of the nervous system
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Summary:Factor VII is essential for coagulation activation by the extrinsic pathway. Hemorrhages of the central nervous system in patients with congenital factor VII deficiency seem to have a higher incidence compared with other congenital coagulopathies. The purpose of this paper is to report two rare cases of subarachnoid hemorrhage and factor VII deficiency. Two cases of women affected by a congenital deficiency of factor VII and subarachnoid hemorrhage are reported. Diagnosis was obtained by cerebral computer tomography; cerebral pan-angiography was normal. Complete coagulation studies were performed showing prothrombin time prolongation and factor VII deficiency. In one patient, family studies revealed the existence of a similar coagulation disorder. We suggest routine coagulation studies in all patients with subarachnoid hemorrhage. Determination of factor VII activity might be performed in patients with normal activated partial thromboplastin time and prolonged prothrombin time.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.25.2.508