Brainstem Involvement in Sjögren's Syndrome‐Related Sensory Neuronopathy

ABSTRACT BACKGROUND AND PURPOSE Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Magnetic resonance imaging (MRI) studies have shown abnormalities limited to T2‐weighted high signal intensity in the posterior columns. M...

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Bibliographic Details
Published in:Journal of neuroimaging 2010-10, Vol.20 (4), p.397-399
Main Authors: Damasceno, Alfredo, França Jr, Marcondes C., Zanardi, Verônica A., Nucci, Anamarli
Format: Article
Language:English
Subjects:
Brain Stem - pathology
Female
Humans
Magnetic Resonance Imaging - methods
Middle Aged
Polyneuropathies - pathology
Sensation Disorders - pathology
Sjogren's Syndrome - pathology
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Summary:ABSTRACT BACKGROUND AND PURPOSE Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Magnetic resonance imaging (MRI) studies have shown abnormalities limited to T2‐weighted high signal intensity in the posterior columns. METHODS AND RESULTS A 65‐year‐old woman with Sjögren syndrome had slowly progressive unsteadiness of gait and limb paresthesias. A blink reflex examination suggested a paramedian brainstem lesion, confirmed by MRI. CONCLUSIONS Sjögren's syndrome‐related SN may be associated with a more diffuse immune‐mediated aggression, involving also the brainstem, and leading to some of the blink reflex abnormalities observed in nonparaneoplastic SN.
ISSN:1051-2284
1552-6569
DOI:10.1111/j.1552-6569.2009.00393.x