Zwitterion-Stabilized Silica Nanoparticles: Toward Nonstick Nano

Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that “zwitterated” nanoparticles did not exhibit a significant increase in hydrodynamic radius. When chal...

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Bibliographic Details
Published in:Langmuir 2010-11, Vol.26 (22), p.16884-16889
Main Authors: Estephan, Zaki G, Jaber, Jad A, Schlenoff, Joseph B
Format: Article
Language:English
Subjects:
Animals
Betaine - analogs & derivatives
Betaine - chemistry
Cattle
Chemistry
Colloidal state and disperse state
Colloids: Surfactants and Self-Assembly, Dispersions, Emulsions, Foams
Exact sciences and technology
General and physical chemistry
Hydrodynamics
Hydrolysis
Light
Nanoparticles - chemistry
Nephelometry and Turbidimetry
Osmolar Concentration
Particle Size
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Scattering, Radiation
Silicon Dioxide - chemistry
Siloxanes - chemistry
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Summary:Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that “zwitterated” nanoparticles did not exhibit a significant increase in hydrodynamic radius. When challenged with 3 M NaCl or 50% fetal bovine serum, aggregation was inhibited for at least 24 h, longer with mild heat treatment, which produced nanoparticles with zero net surface charge. These findings suggest “zwitteration” of silica-capped nanoparticles provides excellent stability for in vivo circulation diagnostics and therapies.
ISSN:0743-7463
1520-5827
DOI:10.1021/la103095d