A Neuroendocrine Marker in Tissues of the Immune System

Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these org...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1985-10, Vol.230 (4721), p.89-90
Main Authors: Angeletti, Ruth Hogue, Hickey, William F.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
APUD cells
Biological and medical sciences
Chromaffin cells
Chromogranins
Chromogranins - analysis
Electrophoresis, Polyacrylamide Gel
Endocrine cells
Epithelial cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gels
Histocytochemistry
Immunobiology
Immunologic research
Immunological research
Immunosorbent Techniques
Liver
Lymph nodes
Lymphoid organs: ontogeny, organization, homing phenomenon
Lymphoid Tissue - analysis
Mononuclear Phagocyte System - analysis
Nerve Tissue Proteins - analysis
Nervous system
Neuroendocrinology
Neurophysiology
Rats
Spleen
Spleen cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin-immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3898368