Passive Protection of Mice against Group A Streptococcal Pharyngeal Infection by Lipoteichoic Acid

Previous studies have shown that lipoteichoic acid (LTA) of group A streptococci plays a central role in the adherence of these organisms to epithelial cells. In this study, intranasal instillation of purified LTA but not deacylated LTA in mice blocked colonization and prevented death after intranas...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-02, Vol.169 (2), p.319-323
Main Authors: Dale, James B., Baird, Robert W., Courtney, Harry S., Hasty, David L., Bronze, Michael S.
Format: Article
Language:English
Subjects:
Animal models
Animals
Antibodies
Antibodies, Bacterial - immunology
Antigens, Bacterial
Bacteria
Bacterial Adhesion
Bacterial diseases
Bacterial Outer Membrane Proteins
Bacterial Proteins - immunology
Biological and medical sciences
Carrier Proteins
Epithelial cells
Experimental bacterial diseases and models
Fatty acids
Female
Infections
Infectious diseases
Lipopolysaccharides - immunology
Major Articles
Medical sciences
Mice
Mice, Inbred BALB C
Microbial colonization
Nasal Mucosa - immunology
Nasal Mucosa - microbiology
Receptors
Streptococcal infections
Streptococcal Infections - microbiology
Streptococcal Infections - prevention & control
Streptococcus
Streptococcus pyogenes - cytology
Streptococcus pyogenes - immunology
Streptococcus pyogenes - pathogenicity
Teichoic Acids - immunology
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Summary:Previous studies have shown that lipoteichoic acid (LTA) of group A streptococci plays a central role in the adherence of these organisms to epithelial cells. In this study, intranasal instillation of purified LTA but not deacylated LTA in mice blocked colonization and prevented death after intranasal challenge infection with group A streptococci. Bacteria pretreated with rabbit antisera against LTA also failed to colonize or infect mice after intranasal challenge. In vitro studies showed that LTA and M protein inhibited adherence of type 24 streptococci to mouse pharyngeal cells. Passive intranasal administration of purified type 24 M protein protected mice from death after challenge infection with type 24 streptococci but had no significant effect on pharyngeal colonization. Surface LTA and M protein may mediate adherence of streptococci to mouse pharyngeal cells, and blocking adherence with LTA prevents colonization and infection in this animal model.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.2.319