Absence of Progesterone Effects on Chlamydial Genital Infection in Female Guinea Pigs

The effect of progesterone alone and in combination with estradiol was investigated in ovariectomized and gonadally intact female guinea pigs infected with the chlamydial agent of guinea pig inclusion conjunctivitis (GPIC). The course of the infection, as determined by the percentage of cells with G...

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Bibliographic Details
Published in:Sexually transmitted diseases 1985-07, Vol.12 (3), p.155-158
Main Authors: PASLEY, JAMES N., RANK, ROGER G., HOUGH, AUBREY J., COHEN, CYNTHIA, BARRON, ALMEN L.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - analysis
Bacterial diseases
Biological and medical sciences
Castration
Chlamydia trachomatis - immunology
Conjunctivitis, Inclusion - immunology
Conjunctivitis, Inclusion - pathology
Conjunctivitis, Inclusion - physiopathology
Estradiol - blood
Estradiol - pharmacology
Estradiol - physiology
Experimental bacterial diseases and models
Female
Guinea Pigs
Infectious diseases
Medical sciences
Progesterone - blood
Progesterone - pharmacology
Progesterone - physiology
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Summary:The effect of progesterone alone and in combination with estradiol was investigated in ovariectomized and gonadally intact female guinea pigs infected with the chlamydial agent of guinea pig inclusion conjunctivitis (GPIC). The course of the infection, as determined by the percentage of cells with GPIC (chlamydial) inclusions in Giemsa-stained vaginal scrapings, was not affected in animals receiving 5.0 mg of progesterone daily. Progesterone had no influence on the enhancement of infection by estradiol. In comparison with sesame oil-treated controls, infection was prolonged by four to six days (P < .05) in animals receiving a combination of 5.0 mg of progesterone plus 1.0 µg of estradiol or 1.0 µg of estradiol alone each day. In ovariectomized animals, estradiol delayed the appearance of IgA antibody in genital secretions, whereas progesterone alone had no effect. Guinea pigs treated with estradiol or progesterone plus estradiol manifested an acute endometritis not observed in animals treated with progesterone alone or in controls receiving sesame oil. Although cervical ectopy, analogous to that seen in women with high levels of progesterone, was identified by histopathology in animals treated with progesterone, no enhancement of the chlamydial infection was observed.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-198507000-00012