2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans , we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of...

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Bibliographic Details
Published in:Nature (London) 1994-03, Vol.368 (6466), p.32-38
Main Authors: Wilson, R, Ainscough, R, Anderson, K, Baynes, C, Berks, M, Bonfield, J, Burton, J, Connell, M, Copsey, T, Cooper, J, Coulson, A, Craxton, M, Dear, S, Du, Z, Durbin, R, Favello, A, Fraser, A, Fulton, L, Gardner, A, Green, P, Hawkins, T, Hillier, L, Jier, M, Johnston, L, Jones, M, Kershaw, J, Kirsten, J, Laisster, N, Latreille, P, Lightning, J, Lloyd, C, Mortimore, B, O'Callaghan, M, Parsons, J, Percy, C, Rifken, L, Roopra, A, Saunders, D, Shownkeen, R, Sims, M, Smaldon, N, Smith, A, Smith, M, Sonnhammer, E, Staden, R, Sulston, J, Thierry-Mieg, J, Thomas, K, Vaudin, M, Vaughan, K, Waterston, R, Watson, A, Weinstock, L, Wilkinson-Sproat, J, Wohldman, P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Chromosome Mapping
Databases, Factual
Deoxyribonucleic acid
DNA
Fundamental and applied biological sciences. Psychology
Genes
Genes, Helminth
Genes, Homeobox
Genes. Genome
Humanities and Social Sciences
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
multidisciplinary
Multigene Family
Repetitive Sequences, Nucleic Acid
RNA, Transfer - genetics
Science
Science (multidisciplinary)
Sequence Analysis, DNA
Worms
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Summary:As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans , we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.
ISSN:0028-0836
1476-4687
DOI:10.1038/368032a0