The haemodynamic effects of intravenous induction. Comparison of the effects of thiopentone and propofol

The haemodynamic changes following induction of anaesthesia with equipotent doses of propofol and thiopentone have been compared. Propofol caused a significant fall in arterial blood pressure and total peripheral resistance, with a slight fall in cardiac output. There were no changes in heart rate....

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Bibliographic Details
Published in:Anaesthesia 1985-08, Vol.40 (8), p.735-740
Main Authors: GROUNDS, R. M, TWIGLEY, A. J, CARLI, F, WHITWAM, J. G, MORGAN, M
Format: Article
Language:English
Subjects:
Anesthesia, Intravenous
Anesthetics - pharmacology
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiac Output - drug effects
Depression, Chemical
Female
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Phenols - pharmacology
Propofol
Respiration - drug effects
Stroke Volume - drug effects
Thiopental - pharmacology
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Summary:The haemodynamic changes following induction of anaesthesia with equipotent doses of propofol and thiopentone have been compared. Propofol caused a significant fall in arterial blood pressure and total peripheral resistance, with a slight fall in cardiac output. There were no changes in heart rate. Apart from an initial, but statistically insignificant increase in heart rate, similar changes were produced by thiopentone, but to a lesser degree. It is concluded that induction of anaesthesia with propofol results in acceptable haemodynamic changes, but that the agent is more depressant to the cardiovascular system than thiopentone.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1985.tb10996.x