How B and T cells talk to each other

The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two ce...

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Bibliographic Details
Published in:Nature (London) 1994-02, Vol.367 (6462), p.425-428
Main Authors: Clark, Edward A, Ledbetter, Jeffrey A
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Antigens, CD - physiology
B-Lymphocytes - physiology
Biological and medical sciences
Cell Adhesion Molecules - physiology
Cell Communication - physiology
Cell interactions
Cellular biology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immune system
Immunity (Disease)
Immunobiology
Lymph nodes
Lymphocyte Activation - physiology
Medical research
Receptors, Antigen, B-Cell - physiology
T-Lymphocytes - physiology
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Summary:The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact have only recently become apparent.
ISSN:0028-0836
1476-4687
DOI:10.1038/367425a0