Ingestive Responses to Homeostatic Challenges in Rats With Ablations of the Anterolateral Neocortex

• Published in: Behavioral neuroscience 1985-02, Vol.99 (1), p.162-174
• Main Authors: Grijalva, Carlos V, Kiefer, Stephen W, Gunion, Mark W, Cooper, Peter H, Novin, Donald
• Format: Article
• Language: English
• Subjects: Animal; Animals; Behavioral psychophysiology; Biological and medical sciences; Body Weight; Brain Mapping; Cerebral Cortex; Cerebral Cortex - physiology; Drinking Behavior - physiology; Feeding Behavior - physiology; Food Deprivation - physiology; Food Intake; Fundamental and applied biological sciences. Psychology; Homeostasis; Male; Neocortex; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Inbred Strains; Water Deprivation; Water Intake; Water-Electrolyte Balance
• ISSN: 0735-7044; 1939-0084
• DOI: 10.1037/0735-7044.99.1.162

Because rats with either anterolateral neocortical or lateral hypothalamic (LH) damage initially display similar feeding and drinking deficits and recovery patterns, the possibility that anterolateral neocortical ablations would also produce similar chronic ingestive impairments to glucoprivic and hydrational challenges was examined. In general, rats with anterolateral neocortical ablations exhibited normal feeding responses to food deprivation and glucoprivation induced by insulin or moderate doses of 2-deoxy- D -glucose (2-DG), but their response to a high dose (500 mg/kg) of 2-DG was impaired. These animals also drank normally in response to hypertonic saline injections and following water deprivation, but only if food was available during the test session, results indicating that they drank prandially. Results indicate that although the anterolateral neocortex and LH are anatomically related, these brain regions appear to be functionally dissimilar in terms of the regulation of ingestion.