MAC reduction of isoflurane by sufentanil

We have shown previously that a plasma fentanyl concentration of 1.67 ng ml−1 reduced the MAC of isoflurane by 50%. By comparing equal degrees of MAC reduction by sufentanil, we may determine the potency ratio of these opioids. Seventy-six patients were allocated randomly to receive predetermined in...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1994-01, Vol.72 (1), p.42-46
Main Authors: BRUNNER, M.D., BRAITHWAITE, P., JHAVERI, R., MCEWAN, A.I., GOODMAN, D.K., SMITH, L.R., GLASS, P.S.A.
Format: Article
Language:English
Subjects:
Adult
Anaesthetics
Anaesthetics, volatile: isoflurane, minimum alveolar concentration
Analgesics
Analgesics, opioid: sufentanil
Anesthesia, General
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Dose-Response Relationship, Drug
Female
Humans
Isoflurane - blood
Male
Medical sciences
Middle Aged
minimum alveolar concentration
Movement - drug effects
Neuropharmacology
opioid: sufentanil
Pharmacology. Drug treatments
Potency
Potency, minimum alveolar concentration
Pulmonary Alveoli - metabolism
Sufentanil - blood
Tidal Volume
volatile: isoflurane
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Summary:We have shown previously that a plasma fentanyl concentration of 1.67 ng ml−1 reduced the MAC of isoflurane by 50%. By comparing equal degrees of MAC reduction by sufentanil, we may determine the potency ratio of these opioids. Seventy-six patients were allocated randomly to receive predetermined infusions of sufentanil, and end-tidal concentrations of isoflurane in oxygen. Blood samples were obtained 10 min after the start of the infusion, and just before and after skin incision. Any purposeful movement by the patient was recorded. The MAC reduction of isoflurane produced by sufentanil was obtained using a logistic regression model. A sufentanil plasma concentration of 0.145 ng ml−1 (95% confidence limits 0.04, 0.26 ng ml−1) resulted in a 50% reduction in the MAC of isoflurane. At a plasma concentration greater than 0.5 ng ml−1, sufentanil exhibited a ceiling effect. (Br. J. Anaesth. 1994; 72: 42–46)
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/72.1.42