Viability criterion of muscle bundles used in the in vitro contracture test in patients with neuromuscular diseases

We have compared the viability criteria of muscle bundles used in the in vitro contracture test for susceptibility to malignant hyperthermia (MH) in a group of 28 patients with various neuromuscular diseases (NMD) and 93 MH-related family patients. In the patients with NMD, this standard test gave o...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1994-01, Vol.72 (1), p.93-97
Main Authors: ADNET, P.J., KRIVOSIC-HORBER, R.M., KRIVOSIC, I., HAUDECOEUR, G., REYFORD, H.G., ADAMANTIDIS, M.M., MEDAHOUI, H.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Caffeine - pharmacology
Complications: malignant hyperthermia
contracture test for MH
Disease Susceptibility
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Halothane - pharmacology
Humans
In Vitro Techniques
Malignant Hyperthermia - diagnosis
Malignant Hyperthermia - physiopathology
Measurement techniques
Medical sciences
Membrane Potentials - physiology
Muscle Contraction - drug effects
Muscles - physiopathology
Neuromuscular Diseases - physiopathology
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Summary:We have compared the viability criteria of muscle bundles used in the in vitro contracture test for susceptibility to malignant hyperthermia (MH) in a group of 28 patients with various neuromuscular diseases (NMD) and 93 MH-related family patients. In the patients with NMD, this standard test gave one positive, six equivocal and 21 negative results. Compared with MH-related family patients, muscle bundles used had significantly smaller resting membrane potentials and smaller predrug twitch tension amplitudes. Some results from the group with NMD were obtained with muscles which were damaged, more rapidly deteriorating, non-standard, or both, and should not be taken to indicate that the patients have the genetic trait for MH. The in vitro contracture test is not always relevant for myopathic muscle (especially dystrophic muscle) and this could explain the lack of specificity for MH. (Br. J. Anaesth. 1994; 72: 93–97)
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/72.1.93