Platelet alpha-adrenergic receptors are not down-regulated during cardiopulmonary bypass

There is poor correlation between the elevated plasma catecholamines and hemodynamic variables during cardiopulmonary bypass. One of the possible mechanisms of the apparent reduced responsiveness to alpha -adrenergic stimulation by elevated catecholamine concentrations might be down-regulation of al...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1985-10, Vol.63 (4), p.449-451
Main Authors: ZUCKER, J. R, AMORY, D. W
Format: Article
Language:English
Subjects:
alpha -adrenergic
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Platelets - metabolism
Blood Platelets - physiology
Cardiopulmonary Bypass
Coronary Artery Bypass
down-regulation
Humans
man
Medical sciences
platelets
Receptors, Adrenergic, alpha - metabolism
Receptors, Adrenergic, alpha - physiology
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
yohimbine
Yohimbine - metabolism
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Summary:There is poor correlation between the elevated plasma catecholamines and hemodynamic variables during cardiopulmonary bypass. One of the possible mechanisms of the apparent reduced responsiveness to alpha -adrenergic stimulation by elevated catecholamine concentrations might be down-regulation of alpha -adrenergic receptors, i.e., a decrease in the number of receptors. Since regulation of platelet alpha -adrenergic receptors may be common to all alpha -adrenergic receptors, the authors measured platelet alpha -adrenergic receptors before and after cardiopulmonary bypass in patients undergoing coronary artery bypass grafting (CABG) surgery.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198510000-00018