Presence of helodermin-like peptides of the VIP-secretin family in mammalian salivary glands and saliva

Helodermin is a biologically active peptide isolated from the venom of the Gila monster lizard ( Heloderma suspectum) whose structure is related to that of vasoactive intestinal peptide and secretin. Using a specific radioimmunoassay based on antisera prepared by immunizing rabbits with natural helo...

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Bibliographic Details
Published in:FEBS letters 1985-10, Vol.190 (1), p.142-146
Main Authors: Robberecht, Patrick, de Neef, Philippe, Vandermeers, André, Vandermeers-Piret, Marie-Claire, Svoboda, Michal, Meuris, Sylvian, de Graef, Jacques, Woussen-Colle, Marie-Claire, Yanaihara, Chizuko, Yanaihara, Noboru, Christophe, Jean
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Chromatography, Gel
Dogs
Fundamental and applied biological sciences. Psychology
Gila monster venom
Helodermin
Humans
Mammalian salivary gland
Peptides - analysis
Proteins
Radioimmunoassay
Rats
Saliva
Saliva - analysis
Salivary Glands - analysis
Secretin - analysis
Secretin/VIP peptide family
Species Specificity
Vasoactive Intestinal Peptide - analysis
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Summary:Helodermin is a biologically active peptide isolated from the venom of the Gila monster lizard ( Heloderma suspectum) whose structure is related to that of vasoactive intestinal peptide and secretin. Using a specific radioimmunoassay based on antisera prepared by immunizing rabbits with natural helodermin, we demonstrated the presence of helodermin-like material in mammalian salivary glands, including parotid, submaxillary and sublingual glands from rat and dog, and parotid and submaxillary glands from man. All helodermin-like materials had an apparent molecular mass of 4–12 kDa. Dog saliva, collected after pilocarpine stimulation, revealed similar immunoreactivity with a major component around 6 kDa.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(85)80445-2