B-cell responses to male-specific antigen(s) in mice

It has been found that B-cell responses to male-specific antigen(s) can be clearly demonstrated by reversed plaque assays. Female mice injected with syngeneic male spleen cells showed significant increases (greater than 100 X in some strains) in the number of immunoglobulin-secreting cells in lymph...

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Bibliographic Details
Published in:Immunogenetics (New York) 1985-01, Vol.22 (3), p.203-210
Main Authors: Hancock, R J, Dresser, D W
Format: Article
Language:English
Subjects:
Animals
Antibody-Producing Cells - immunology
B-Lymphocytes - immunology
Dose-Response Relationship, Immunologic
Female
H-Y Antigen - immunology
Heterozygote
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Isoantibodies - biosynthesis
Male
Mice
Mice, Inbred Strains
Minor Histocompatibility Loci
Spleen - immunology
Time Factors
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Summary:It has been found that B-cell responses to male-specific antigen(s) can be clearly demonstrated by reversed plaque assays. Female mice injected with syngeneic male spleen cells showed significant increases (greater than 100 X in some strains) in the number of immunoglobulin-secreting cells in lymph nodes draining the injection site. There was a variation in B-cell responsiveness between strains and this correlated only partially with previously reported T-cell responsiveness to the H-Y antigen. C57BL (H-2b) mice were among the most responsive, while CBA (H-2k), (CBA X C57BL)F1, and BALB/c (H-2d) were all much less responsive. These results apparently open up a new approach to the investigation of B-cell responses to male-specific antigen(s).
ISSN:0093-7711
1432-1211
DOI:10.1007/BF00404479