A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery

Summary Twenty patients, scheduled for minor gynaecological surgery, were studied. Anaesthesia was induced with propofol and maintained with oxygen, nitrous oxide and enflurane. Patients were randomly allocated to two groups: group 1 were given alfentanil 0.2 mg; group 2 were given morphine 5 mg. Th...

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Published in:Anaesthesia 1994-02, Vol.49 (2), p.155-156
Main Authors: Bennett, M. W. R., Shah, M. V., Bembridge, J. L.
Format: Article
Language:English
Subjects:
Acetaminophen - blood
Adult
alfentanil
Alfentanil - pharmacology
Analgesia - methods
Analgesics
Biological and medical sciences
Female
Gastric Emptying - drug effects
Gastrointestinal tract
gastric emptying
Humans
Intraoperative Period
Medical sciences
Middle Aged
Minor Surgical Procedures
morphine
Morphine - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Time Factors
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cited_by cdi_FETCH-LOGICAL-c3665-d8044f71aefcc2d63f100eaf25960b56058a7cb30dfeda26c4b36204befc8f783
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container_title Anaesthesia
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creator Bennett, M. W. R.
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description Summary Twenty patients, scheduled for minor gynaecological surgery, were studied. Anaesthesia was induced with propofol and maintained with oxygen, nitrous oxide and enflurane. Patients were randomly allocated to two groups: group 1 were given alfentanil 0.2 mg; group 2 were given morphine 5 mg. The rate of gastric emptying was measured indirectly by the paracetamol absorption technique. The results showed that morphine caused greater delay in gastric emptying compared with alfentanil (p < 0.05). The observed effect on gastric emptying rate may potentially affect the risk of peri‐operative regurgitation and aspiration. This study provides further evidence that in short day‐case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra‐operative opioid.
doi_str_mv 10.1111/j.1365-2044.1994.tb03376.x
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This study provides further evidence that in short day‐case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra‐operative opioid.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1994.tb03376.x</identifier><identifier>PMID: 8129128</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetaminophen - blood ; Adult ; alfentanil ; Alfentanil - pharmacology ; Analgesia - methods ; Analgesics ; Biological and medical sciences ; Female ; Gastric Emptying - drug effects ; Gastrointestinal tract; gastric emptying ; Humans ; Intraoperative Period ; Medical sciences ; Middle Aged ; Minor Surgical Procedures ; morphine ; Morphine - pharmacology ; Neuropharmacology ; Pharmacology. 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This study provides further evidence that in short day‐case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra‐operative opioid.</description><subject>Acetaminophen - blood</subject><subject>Adult</subject><subject>alfentanil</subject><subject>Alfentanil - pharmacology</subject><subject>Analgesia - methods</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastrointestinal tract; gastric emptying</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minor Surgical Procedures</subject><subject>morphine</subject><subject>Morphine - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3665-d8044f71aefcc2d63f100eaf25960b56058a7cb30dfeda26c4b36204befc8f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acetaminophen - blood</topic><topic>Adult</topic><topic>alfentanil</topic><topic>Alfentanil - pharmacology</topic><topic>Analgesia - methods</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastrointestinal tract; gastric emptying</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minor Surgical Procedures</topic><topic>morphine</topic><topic>Morphine - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bennett, M. W. R.</creatorcontrib><creatorcontrib>Shah, M. V.</creatorcontrib><creatorcontrib>Bembridge, J. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bennett, M. W. R.</au><au>Shah, M. V.</au><au>Bembridge, J. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1994-02</date><risdate>1994</risdate><volume>49</volume><issue>2</issue><spage>155</spage><epage>156</epage><pages>155-156</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary Twenty patients, scheduled for minor gynaecological surgery, were studied. Anaesthesia was induced with propofol and maintained with oxygen, nitrous oxide and enflurane. Patients were randomly allocated to two groups: group 1 were given alfentanil 0.2 mg; group 2 were given morphine 5 mg. The rate of gastric emptying was measured indirectly by the paracetamol absorption technique. The results showed that morphine caused greater delay in gastric emptying compared with alfentanil (p &lt; 0.05). The observed effect on gastric emptying rate may potentially affect the risk of peri‐operative regurgitation and aspiration. This study provides further evidence that in short day‐case procedures, when oral medication may be required postoperatively, alfentanil may be preferable to morphine as an intra‐operative opioid.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8129128</pmid><doi>10.1111/j.1365-2044.1994.tb03376.x</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
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subjects Acetaminophen - blood
Adult
alfentanil
Alfentanil - pharmacology
Analgesia - methods
Analgesics
Biological and medical sciences
Female
Gastric Emptying - drug effects
Gastrointestinal tract
gastric emptying
Humans
Intraoperative Period
Medical sciences
Middle Aged
Minor Surgical Procedures
morphine
Morphine - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Time Factors
title A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery
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