Dependence on p75 for Innervation of Some Sympathetic Targets

The low-affinity neurotrophin receptor p75 binds all neurotrophins with similar affinity. For elucidation of its function, mice bearing a null mutation in the p75 locus were generated. Examination of sympathetic innervation of target tissues revealed that pineal glands lacked innervation and sweat g...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-03, Vol.263 (5152), p.1447-1449
Main Authors: Lee, Kuo-Fen, Bachman, Kathy, Landis, Story, Jaenisch, Rudolf
Format: Article
Language:English
Subjects:
Adrenergic Fibers - physiology
Adrenergic Fibers - ultrastructure
Adults
Animals
Axons
Axons - physiology
Axons - ultrastructure
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Innervation
Mice
Mutation
Nerves
Neurites
Neurons
Neuroscience
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Pilocarpine - pharmacology
Pineal gland
Pineal Gland - innervation
Population growth
Receptors, Nerve Growth Factor - genetics
Receptors, Nerve Growth Factor - physiology
Sweat glands
Sweat Glands - chemistry
Sweat Glands - drug effects
Sweat Glands - innervation
Sweat Glands - physiology
Sweating
Vasoactive Intestinal Peptide - analysis
Vertebrates: nervous system and sense organs
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Summary:The low-affinity neurotrophin receptor p75 binds all neurotrophins with similar affinity. For elucidation of its function, mice bearing a null mutation in the p75 locus were generated. Examination of sympathetic innervation of target tissues revealed that pineal glands lacked innervation and sweat gland innervation was absent or reduced in particular footpads. The absence of adult innervation reflects the failure of axons to reach these targets during development rather than a target deficit. These results indicate that p75 facilitates development of specific populations of sympathetic neurons, for which it may support axon growth.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8128229