Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel

The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococ...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-04, Vol.169 (4), p.847-852
Main Authors: Zangwill, Kenneth M., Stout, Ronald W., Carlone, George M., Pais, Lorna, Harekeh, Hani, Mitchell, Susan, Wolfe, William H., Blackwood, Vaden, Plikaytis, Brian D., Wenger, Jay D.
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Air forces
Antibodies
Antibodies, Bacterial - biosynthesis
Antibody formation
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacterial Vaccines - immunology
Biological and medical sciences
Cross-Sectional Studies
Enzyme linked immunosorbent assay
European Continental Ancestry Group
Female
Human bacterial diseases
Humans
Infectious diseases
Major Articles
Male
Medical sciences
Meningococcal Vaccines
Military Personnel
Military recruitment
Neisseria meningitidis
Neisseria meningitidis - immunology
Polysaccharides
Preventive medicine
Retrospective Studies
Sex Factors
Time Factors
Vaccination
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Summary:The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococcal vaccine were evaluated in US Air Force personnel. In a retrospective cross-sectional study, blood samples were obtained from ∼40 personnel before vaccination, at 1 and 4-6 months, and at 2, 3, 4, 6, 8, and 10 years after vaccination. Total anti-group A and -group C capsular antibody levels and bactericidal activity peaked 1 month after vaccination and declined substantially by 2 years. At each interval, significantly higher levels oftotal antibody and bactericidal activity were detected than before vaccination. Anti-capsular antibodies and bactericidal activity persisted for up to 10 years after immunization. These and further studies on the serologic measure of protection against meningococcal disease are important for evaluation of candidate vaccines and development of recommendations for immunization.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.4.847