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Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel
The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococ...
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| Published in: | The Journal of infectious diseases 1994-04, Vol.169 (4), p.847-852 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 852 |
| container_issue | 4 |
| container_start_page | 847 |
| container_title | The Journal of infectious diseases |
| container_volume | 169 |
| creator | Zangwill, Kenneth M. Stout, Ronald W. Carlone, George M. Pais, Lorna Harekeh, Hani Mitchell, Susan Wolfe, William H. Blackwood, Vaden Plikaytis, Brian D. Wenger, Jay D. |
| description | The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococcal vaccine were evaluated in US Air Force personnel. In a retrospective cross-sectional study, blood samples were obtained from ∼40 personnel before vaccination, at 1 and 4-6 months, and at 2, 3, 4, 6, 8, and 10 years after vaccination. Total anti-group A and -group C capsular antibody levels and bactericidal activity peaked 1 month after vaccination and declined substantially by 2 years. At each interval, significantly higher levels oftotal antibody and bactericidal activity were detected than before vaccination. Anti-capsular antibodies and bactericidal activity persisted for up to 10 years after immunization. These and further studies on the serologic measure of protection against meningococcal disease are important for evaluation of candidate vaccines and development of recommendations for immunization. |
| doi_str_mv | 10.1093/infdis/169.4.847 |
| format | article |
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Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococcal vaccine were evaluated in US Air Force personnel. In a retrospective cross-sectional study, blood samples were obtained from ∼40 personnel before vaccination, at 1 and 4-6 months, and at 2, 3, 4, 6, 8, and 10 years after vaccination. Total anti-group A and -group C capsular antibody levels and bactericidal activity peaked 1 month after vaccination and declined substantially by 2 years. At each interval, significantly higher levels oftotal antibody and bactericidal activity were detected than before vaccination. Anti-capsular antibodies and bactericidal activity persisted for up to 10 years after immunization. These and further studies on the serologic measure of protection against meningococcal disease are important for evaluation of candidate vaccines and development of recommendations for immunization.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/169.4.847</identifier><identifier>PMID: 8133100</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; African Continental Ancestry Group ; Air forces ; Antibodies ; Antibodies, Bacterial - biosynthesis ; Antibody formation ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Bacterial Vaccines - immunology ; Biological and medical sciences ; Cross-Sectional Studies ; Enzyme linked immunosorbent assay ; European Continental Ancestry Group ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Major Articles ; Male ; Medical sciences ; Meningococcal Vaccines ; Military Personnel ; Military recruitment ; Neisseria meningitidis ; Neisseria meningitidis - immunology ; Polysaccharides ; Preventive medicine ; Retrospective Studies ; Sex Factors ; Time Factors ; Vaccination</subject><ispartof>The Journal of infectious diseases, 1994-04, Vol.169 (4), p.847-852</ispartof><rights>Copyright 1994 The University of Chicago</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-ccc8fddd22145434e6bf63d5ee33ad646fa9413599fb2c8bb3f21301c8b465f63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30113839$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30113839$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4098507$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8133100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zangwill, Kenneth M.</creatorcontrib><creatorcontrib>Stout, Ronald W.</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Pais, Lorna</creatorcontrib><creatorcontrib>Harekeh, Hani</creatorcontrib><creatorcontrib>Mitchell, Susan</creatorcontrib><creatorcontrib>Wolfe, William H.</creatorcontrib><creatorcontrib>Blackwood, Vaden</creatorcontrib><creatorcontrib>Plikaytis, Brian D.</creatorcontrib><creatorcontrib>Wenger, Jay D.</creatorcontrib><title>Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococcal vaccine were evaluated in US Air Force personnel. In a retrospective cross-sectional study, blood samples were obtained from ∼40 personnel before vaccination, at 1 and 4-6 months, and at 2, 3, 4, 6, 8, and 10 years after vaccination. Total anti-group A and -group C capsular antibody levels and bactericidal activity peaked 1 month after vaccination and declined substantially by 2 years. At each interval, significantly higher levels oftotal antibody and bactericidal activity were detected than before vaccination. Anti-capsular antibodies and bactericidal activity persisted for up to 10 years after immunization. These and further studies on the serologic measure of protection against meningococcal disease are important for evaluation of candidate vaccines and development of recommendations for immunization.</description><subject>Adult</subject><subject>African Continental Ancestry Group</subject><subject>Air forces</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antibody formation</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme linked immunosorbent assay</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningococcal Vaccines</subject><subject>Military Personnel</subject><subject>Military recruitment</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - immunology</subject><subject>Polysaccharides</subject><subject>Preventive medicine</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFUctuEzEUtRCohLZ7NkheIHaT2nM9nvEyaglFKlDRhxAby-MHuEzs1J5Izd_X0YSIHat7pPOQ7jkIvaVkTomAMx-c8fmMcjFn8461L9CMNtBWnFN4iWaE1HVFOyFeozc5PxBCGPD2CB11FIASMkPuYpPU6GPA0eFFGH0fzRZ_t3kdQ7ZYudEm_MUGH35FHbVWA76OwzYrrX-r5I3F9wX6MGX4gO9u8MInvIxJW3xtU44h2OEEvXJqyPZ0f4_R3fLj7flldfXt0-fzxVWlGWVjpbXunDGmrilrGDDLe8fBNNYCKMMZd0owCo0Qrq911_fgagqEFsh4U6TH6MOUu07xcWPzKFc-azsMKti4ybLlIAQw8V9haZSThtZFSCahTjHnZJ1cJ79SaSspkbsN5LTBziGZLBsUy7t99qZfWXMw7Esv_Ps9r3Ip1CUVdAn4K2NEdA35J-YhjzEd6PIuhQ52L1QT7_Nonw68Sn8kb6Ft5OWPn5LcLi9Ex75KDs8Idqmj</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Zangwill, Kenneth M.</creator><creator>Stout, Ronald W.</creator><creator>Carlone, George M.</creator><creator>Pais, Lorna</creator><creator>Harekeh, Hani</creator><creator>Mitchell, Susan</creator><creator>Wolfe, William H.</creator><creator>Blackwood, Vaden</creator><creator>Plikaytis, Brian D.</creator><creator>Wenger, Jay D.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel</title><author>Zangwill, Kenneth M. ; Stout, Ronald W. ; Carlone, George M. ; Pais, Lorna ; Harekeh, Hani ; Mitchell, Susan ; Wolfe, William H. ; Blackwood, Vaden ; Plikaytis, Brian D. ; Wenger, Jay D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ccc8fddd22145434e6bf63d5ee33ad646fa9413599fb2c8bb3f21301c8b465f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>African Continental Ancestry Group</topic><topic>Air forces</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Antibody formation</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme linked immunosorbent assay</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meningococcal Vaccines</topic><topic>Military Personnel</topic><topic>Military recruitment</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - immunology</topic><topic>Polysaccharides</topic><topic>Preventive medicine</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zangwill, Kenneth M.</creatorcontrib><creatorcontrib>Stout, Ronald W.</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Pais, Lorna</creatorcontrib><creatorcontrib>Harekeh, Hani</creatorcontrib><creatorcontrib>Mitchell, Susan</creatorcontrib><creatorcontrib>Wolfe, William H.</creatorcontrib><creatorcontrib>Blackwood, Vaden</creatorcontrib><creatorcontrib>Plikaytis, Brian D.</creatorcontrib><creatorcontrib>Wenger, Jay D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zangwill, Kenneth M.</au><au>Stout, Ronald W.</au><au>Carlone, George M.</au><au>Pais, Lorna</au><au>Harekeh, Hani</au><au>Mitchell, Susan</au><au>Wolfe, William H.</au><au>Blackwood, Vaden</au><au>Plikaytis, Brian D.</au><au>Wenger, Jay D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>169</volume><issue>4</issue><spage>847</spage><epage>852</epage><pages>847-852</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The long-term kinetics of the immunologic response after vaccination of adults with Neisseria meningitidis polysaccharide vaccine is unknown. Total meningococcal anti-capsular antibody response (measured by ELISA) and serum bactericidal activity after routine vaccination with quadrivalent meningococcal vaccine were evaluated in US Air Force personnel. In a retrospective cross-sectional study, blood samples were obtained from ∼40 personnel before vaccination, at 1 and 4-6 months, and at 2, 3, 4, 6, 8, and 10 years after vaccination. Total anti-group A and -group C capsular antibody levels and bactericidal activity peaked 1 month after vaccination and declined substantially by 2 years. At each interval, significantly higher levels oftotal antibody and bactericidal activity were detected than before vaccination. Anti-capsular antibodies and bactericidal activity persisted for up to 10 years after immunization. These and further studies on the serologic measure of protection against meningococcal disease are important for evaluation of candidate vaccines and development of recommendations for immunization.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8133100</pmid><doi>10.1093/infdis/169.4.847</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1994-04, Vol.169 (4), p.847-852 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Adult African Continental Ancestry Group Air forces Antibodies Antibodies, Bacterial - biosynthesis Antibody formation Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Bacterial Vaccines - immunology Biological and medical sciences Cross-Sectional Studies Enzyme linked immunosorbent assay European Continental Ancestry Group Female Human bacterial diseases Humans Infectious diseases Major Articles Male Medical sciences Meningococcal Vaccines Military Personnel Military recruitment Neisseria meningitidis Neisseria meningitidis - immunology Polysaccharides Preventive medicine Retrospective Studies Sex Factors Time Factors Vaccination |
| title | Duration of Antibody Response after Meningococcal Polysaccharide Vaccination in US Air Force Personnel |
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