Provirus Copy Number to Predict Disease Progression in Asymptomatic Human Immunodeficiency Virus Type 1 Infection

To evaluate the prognostic value of provirus copy number through quantitative DNA polymerase chain reaction (PCR) in early stages of human immunodeficiency virus type 1 (HIV-1) infection, 42 untreated and asymptomatic HIV-L-seropositive subjects with baseline CD4+ cell counts >200 × 106/L were in...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-04, Vol.169 (4), p.882-885
Main Authors: Chevret, s., Kirstetter, M., Mariotti, M., Lefrère, F., Frottier, J., Lefrère, J .-J.
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS/HIV
Biological and medical sciences
CD4-Positive T-Lymphocytes - microbiology
Cell lines
Cohort Studies
Concise Communications
Disease progression
DNA, Viral - analysis
Female
Follow-Up Studies
HIV 1
HIV Infections - etiology
HIV Infections - microbiology
HIV-1 - genetics
HIV-1 - growth & development
human immunodeficiency virus 1
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Leukocyte Count
Lymphocytes
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Prognosis
Prospective Studies
Proviruses
Proviruses - genetics
Proviruses - growth & development
T lymphocytes
Viruses
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Summary:To evaluate the prognostic value of provirus copy number through quantitative DNA polymerase chain reaction (PCR) in early stages of human immunodeficiency virus type 1 (HIV-1) infection, 42 untreated and asymptomatic HIV-L-seropositive subjects with baseline CD4+ cell counts >200 × 106/L were included in a prospective study and followed over a median of 27 months. Disease progression was defined as decrease in CD4+ cells to
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.4.882