Spinal movements in ankylosing spondylitis and the effect of treatment

Fourteen male patients with ankylosing spondylitis, admitted for a 2-week period of inpatient treatment, had their spinal mobility assessed on admission and at the end of treatment by clinical measures and a three-dimensional radiographic technique. The patients were given injections of low-dose cor...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1985-06, Vol.10 (5), p.472-474
Main Authors: PEARCY, M. J, WORDSWORTH, B. P, PORTEK, I, MOWAT, A. G
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - therapeutic use
Adult
Biological and medical sciences
Diseases of the osteoarticular system
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Movement - drug effects
Radiography
Spondylitis, Ankylosing - diagnostic imaging
Spondylitis, Ankylosing - drug therapy
Spondylitis, Ankylosing - physiopathology
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Summary:Fourteen male patients with ankylosing spondylitis, admitted for a 2-week period of inpatient treatment, had their spinal mobility assessed on admission and at the end of treatment by clinical measures and a three-dimensional radiographic technique. The patients were given injections of low-dose corticotrophin (ACTH) or placebo under a double-blind protocol. Initially all the patients had restricted movements compared with normal. After treatment all showed some improvement of mobility but no additional benefit accrued from ACTH. Clinical measures of mobility must be interpreted with care as the changes in these measurements were not closely reflected in the lumbar movements measured radiographically. Changes seen in plain radiographs were of little predictive value for improvements in mobility.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-198506000-00013