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Mice lacking brain-derived neurotrophic factor develop with sensory deficits
DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors 1,2 . Brain-derived neurotrophic factor 3 (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro 4–6 , and of central motor neurons as well as...
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| Published in: | Nature (London) 1994-03, Vol.368 (6467), p.147-150 |
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| creator | Ernfors, Patrik Lee, Kuo-Fen Jaenisch, Rudolf |
| description | DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors
1,2
. Brain-derived neurotrophic factor
3
(BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons
in vitro
4–6
, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development
7–9
. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions
8,10–12
. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations. |
| doi_str_mv | 10.1038/368147a0 |
| format | article |
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1,2
. Brain-derived neurotrophic factor
3
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in vitro
4–6
, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development
7–9
. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions
8,10–12
. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/368147a0</identifier><identifier>PMID: 8139657</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Brain ; Brain-Derived Neurotrophic Factor ; Cell Death ; Cell Line ; Classical genetics, quantitative genetics, hybrids ; Ear, Inner - innervation ; Embryo, Mammalian - innervation ; Embryonic and Fetal Development ; Fundamental and applied biological sciences. Psychology ; Ganglia - embryology ; Ganglia - pathology ; Genetics of eukaryotes. Biological and molecular evolution ; Humanities and Social Sciences ; letter ; Mice ; Mice, Inbred BALB C ; Mice, Mutant Strains ; Movement Disorders - genetics ; multidisciplinary ; Mutation ; Nerve Tissue Proteins - deficiency ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Nervous System - embryology ; Nervous System - pathology ; Neurology ; Neurons, Afferent - pathology ; Peripheral Nervous System - embryology ; Peripheral Nervous System - pathology ; Rodents ; Science ; Science (multidisciplinary) ; Senses ; Stem Cells ; Vertebrata</subject><ispartof>Nature (London), 1994-03, Vol.368 (6467), p.147-150</ispartof><rights>Springer Nature Limited 1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Mar 10, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b163068eeb799aab5b239ebfe4ac466738f8ec300ed03b3c6cf8e3eaf24c55da3</citedby><cites>FETCH-LOGICAL-c422t-b163068eeb799aab5b239ebfe4ac466738f8ec300ed03b3c6cf8e3eaf24c55da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3941901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8139657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ernfors, Patrik</creatorcontrib><creatorcontrib>Lee, Kuo-Fen</creatorcontrib><creatorcontrib>Jaenisch, Rudolf</creatorcontrib><title>Mice lacking brain-derived neurotrophic factor develop with sensory deficits</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors
1,2
. Brain-derived neurotrophic factor
3
(BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons
in vitro
4–6
, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development
7–9
. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions
8,10–12
. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain-Derived Neurotrophic Factor</subject><subject>Cell Death</subject><subject>Cell Line</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Ear, Inner - innervation</subject><subject>Embryo, Mammalian - innervation</subject><subject>Embryonic and Fetal Development</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia - embryology</subject><subject>Ganglia - pathology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Mutant Strains</subject><subject>Movement Disorders - genetics</subject><subject>multidisciplinary</subject><subject>Mutation</subject><subject>Nerve Tissue Proteins - deficiency</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Nervous System - embryology</subject><subject>Nervous System - pathology</subject><subject>Neurology</subject><subject>Neurons, Afferent - pathology</subject><subject>Peripheral Nervous System - embryology</subject><subject>Peripheral Nervous System - pathology</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Senses</subject><subject>Stem Cells</subject><subject>Vertebrata</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqF0VFL5DAQAOAgyrp6gn9AKSJyPvScNGmaPIqoJ6z4cvdc0nSq0W6yJq2H_97I7iocgk9DMh-TyQwh-xR-UWDyjAlJeaVhg0xTFDkXstokU4BC5iCZ2CY7MT4CQEkrPiETSZkSZTUls1trMOu1ebLuPmuCti5vMdgXbDOHY_BD8IsHa7JOm8GHrMUX7P0i-2eHhyyiiz68psvOGjvEH2Sr033EvVXcJX-vLv9c_M5nd9c3F-ez3PCiGPKGCgZCIjaVUlo3ZVMwhU2HXBsuRMVkJ9EwAGyBNcwIk84MdVdwU5atZrvkZFl3EfzziHGo5zYa7Hvt0I-xrgSHSpbyW0jT2BSDIsGj_-CjH4NLn6gL4LxUoERCP5fIBB9jwK5eBDvX4bWmUL-voV6vIdGDVb2xmWP7AVdzT_njVV5Ho_suaGds_GBMcaqAJna6ZDFl3D2Gz7a-ePJwaZ0exoCftdbgDViBpjQ</recordid><startdate>19940310</startdate><enddate>19940310</enddate><creator>Ernfors, Patrik</creator><creator>Lee, Kuo-Fen</creator><creator>Jaenisch, Rudolf</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19940310</creationdate><title>Mice lacking brain-derived neurotrophic factor develop with sensory deficits</title><author>Ernfors, Patrik ; Lee, Kuo-Fen ; Jaenisch, Rudolf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-b163068eeb799aab5b239ebfe4ac466738f8ec300ed03b3c6cf8e3eaf24c55da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain-Derived Neurotrophic Factor</topic><topic>Cell Death</topic><topic>Cell Line</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Ear, Inner - innervation</topic><topic>Embryo, Mammalian - innervation</topic><topic>Embryonic and Fetal Development</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ernfors, Patrik</au><au>Lee, Kuo-Fen</au><au>Jaenisch, Rudolf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mice lacking brain-derived neurotrophic factor develop with sensory deficits</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1994-03-10</date><risdate>1994</risdate><volume>368</volume><issue>6467</issue><spage>147</spage><epage>150</epage><pages>147-150</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors
1,2
. Brain-derived neurotrophic factor
3
(BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons
in vitro
4–6
, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development
7–9
. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions
8,10–12
. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8139657</pmid><doi>10.1038/368147a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1994-03, Vol.368 (6467), p.147-150 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76407858 |
| source | Nature |
| subjects | Animals Animals, Newborn Biological and medical sciences Brain Brain-Derived Neurotrophic Factor Cell Death Cell Line Classical genetics, quantitative genetics, hybrids Ear, Inner - innervation Embryo, Mammalian - innervation Embryonic and Fetal Development Fundamental and applied biological sciences. Psychology Ganglia - embryology Ganglia - pathology Genetics of eukaryotes. Biological and molecular evolution Humanities and Social Sciences letter Mice Mice, Inbred BALB C Mice, Mutant Strains Movement Disorders - genetics multidisciplinary Mutation Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Nervous System - embryology Nervous System - pathology Neurology Neurons, Afferent - pathology Peripheral Nervous System - embryology Peripheral Nervous System - pathology Rodents Science Science (multidisciplinary) Senses Stem Cells Vertebrata |
| title | Mice lacking brain-derived neurotrophic factor develop with sensory deficits |
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