Five cases of brain injury following amniocentesis in mid-term pregnancy

This paper describes the neuroimaging and neuropathological findings in five cases of severe brain damage after traumatic mid-trimester amniocentesis, all performed between 1986 and 1994. Although fetal injury after amniocentesis has been reported, reports of brain injury are infrequent. Continuous...

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Bibliographic Details
Published in:Developmental medicine and child neurology 2000-08, Vol.42 (8), p.554-560, Article S0012162200001043
Main Authors: Squier, M, Chamberlain, P, Zaiwalla, Z, Anslow, P, Oxbury, J, Gould, S, McShane, M A
Format: Article
Language:English
Subjects:
Adult
Amniocentesis - adverse effects
Amniocentesis - methods
Brain - growth & development
Brain Injuries - etiology
Case Reports
False Negative Reactions
Female
Humans
Infant, Newborn
Middle Aged
Pregnancy
Pregnancy Complications
Pregnancy Trimester, Second
Retrospective Studies
Risk Assessment
Ultrasonography, Interventional
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Summary:This paper describes the neuroimaging and neuropathological findings in five cases of severe brain damage after traumatic mid-trimester amniocentesis, all performed between 1986 and 1994. Although fetal injury after amniocentesis has been reported, reports of brain injury are infrequent. Continuous ultrasound monitoring may reduce the risk of fetal injury but follow-up ultrasound scans can be falsely reassuring. Withdrawal of blood-stained fluid, particularly if it contains tissue fragments, should alert the operator to the possibility of fetal damage. Histological examination of such tissue fragments may confirm the nature of the fetal damage. The consequences of fetal brain injury are severe, all five of our cases showed evidence of disruption of brain development compatible with mid-term injury. Obstetricians and their patients should be aware of the small but significant risk of brain damage after mid-term amniocentesis.
ISSN:0012-1622
1469-8749
DOI:10.1017/S0012162200001043