Monoamine and diamine oxidase activity in the diagnosis of carcinoid tumors

This study determines if one could distinguish foregut from midgut carcinoid tumors by quantitative measurement of the monoamine oxidase (MAO) and diamine oxidase (DAO) activities in homogenates of tumors. The MAO activity of 16 foregut carcinoid tumors (1850 ± 342 pmol/mg/minute) was significantly...

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Bibliographic Details
Published in:Cancer 1985-12, Vol.56 (12), p.2855-2860
Main Author: Feldman, Jerome M.
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - metabolism
Apudoma - classification
Apudoma - diagnosis
Apudoma - secondary
Biological and medical sciences
Bronchial Neoplasms - classification
Bronchial Neoplasms - diagnosis
Bronchial Neoplasms - secondary
Carcinoid Tumor - classification
Carcinoid Tumor - diagnosis
Carcinoid Tumor - secondary
Clinical Enzyme Tests
Cytosol - enzymology
Digestive System Neoplasms - classification
Digestive System Neoplasms - diagnosis
Digestive System Neoplasms - secondary
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Kinetics
Medical sciences
Mitochondria - enzymology
Monoamine Oxidase - metabolism
Monoamine Oxidase Inhibitors - pharmacology
Pancreatic Neoplasms - classification
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - secondary
Tumors
Citations: Items that this one cites
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Summary:This study determines if one could distinguish foregut from midgut carcinoid tumors by quantitative measurement of the monoamine oxidase (MAO) and diamine oxidase (DAO) activities in homogenates of tumors. The MAO activity of 16 foregut carcinoid tumors (1850 ± 342 pmol/mg/minute) was significantly higher than the MAO activity of 11 midgut carcinoid tumors (407 ± 43 pmol/mg/minute, P < 0.01) with no overlap between the groups. Although all ten of the midgut carcinoids had measurable DAO activity (720 ± 190 pmol/mg/minute), with the exception of one duodenal carcinoid tumor (33 pmol/mg/minute) the nine foregut carcinoid tumors evaluated did not have detectable DAO activity. The MAO activity of all of the foregut carcinoids was higher than that of 6 islet cell tumors, 28 paragangliomas, and 12 medullary carcinomas of the thyroid. Quantitative MAO and DAO activity may be useful in distinguishing foregut carcinoid tumors from other related tumors.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19851215)56:12<2855::AID-CNCR2820561223>3.0.CO;2-D