Possible implications of CpG avoidance in the flatworm Schistosoma mansoni

We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. Our results show CpG avoidance whereas TpG and CpA frequencies are over the expected values. These characteristics are similar to the biases displayed by methylated genomes...

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Bibliographic Details
Published in:Journal of molecular evolution 1994-01, Vol.38 (1), p.36-40
Main Authors: Musto, H, Rodriguez-Maseda, H, Alvarez, F, Tort, J
Format: Article
Language:English
Subjects:
Animals
Base Composition
Biological and medical sciences
Dinucleoside Phosphates - genetics
DNA - genetics
DNA, Ribosomal - genetics
Fundamental and applied biological sciences. Psychology
Genes. Genome
GENOMAS
GENOME
Introns
METHYLATION
METILACION
Molecular and cellular biology
Molecular genetics
NUCLEOTIDE
NUCLEOTIDOS
Protein Biosynthesis
Repetitive Sequences, Nucleic Acid
SCHISTOSOMA MANSONI
Schistosoma mansoni - genetics
SECUENCIA NUCLEICA
SEQUENCE NUCLEIQUE
TECHNIQUE ANALYTIQUE
TECNICAS ANALITICAS
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Summary:We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. Our results show CpG avoidance whereas TpG and CpA frequencies are over the expected values. These characteristics are similar to the biases displayed by methylated genomes, but in platyhelminths 5mC has not been detected by biochemical methods. The possible implications of this CpG shortage are discussed
ISSN:0022-2844
1432-1432
DOI:10.1007/BF00175493