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Possible implications of CpG avoidance in the flatworm Schistosoma mansoni

We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. Our results show CpG avoidance whereas TpG and CpA frequencies are over the expected values. These characteristics are similar to the biases displayed by methylated genomes...

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Published in:	Journal of molecular evolution 1994-01, Vol.38 (1), p.36-40
Main Authors:	Musto, H, Rodriguez-Maseda, H, Alvarez, F, Tort, J
Format:	Article
Language:	English
Subjects:	Animals Base Composition Biological and medical sciences Dinucleoside Phosphates - genetics DNA - genetics DNA, Ribosomal - genetics Fundamental and applied biological sciences. Psychology Genes. Genome GENOMAS GENOME Introns METHYLATION METILACION Molecular and cellular biology Molecular genetics NUCLEOTIDE NUCLEOTIDOS Protein Biosynthesis Repetitive Sequences, Nucleic Acid SCHISTOSOMA MANSONI Schistosoma mansoni - genetics SECUENCIA NUCLEICA SEQUENCE NUCLEIQUE TECHNIQUE ANALYTIQUE TECNICAS ANALITICAS
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container_title	Journal of molecular evolution
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creator	Musto, H Rodriguez-Maseda, H Alvarez, F Tort, J
description	We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. Our results show CpG avoidance whereas TpG and CpA frequencies are over the expected values. These characteristics are similar to the biases displayed by methylated genomes, but in platyhelminths 5mC has not been detected by biochemical methods. The possible implications of this CpG shortage are discussed
doi_str_mv	10.1007/BF00175493
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Genome</topic><topic>GENOMAS</topic><topic>GENOME</topic><topic>Introns</topic><topic>METHYLATION</topic><topic>METILACION</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>NUCLEOTIDE</topic><topic>NUCLEOTIDOS</topic><topic>Protein Biosynthesis</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>SCHISTOSOMA MANSONI</topic><topic>Schistosoma mansoni - genetics</topic><topic>SECUENCIA NUCLEICA</topic><topic>SEQUENCE NUCLEIQUE</topic><topic>TECHNIQUE ANALYTIQUE</topic><topic>TECNICAS ANALITICAS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Musto, H</creatorcontrib><creatorcontrib>Rodriguez-Maseda, H</creatorcontrib><creatorcontrib>Alvarez, F</creatorcontrib><creatorcontrib>Tort, J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Musto, H</au><au>Rodriguez-Maseda, H</au><au>Alvarez, F</au><au>Tort, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible implications of CpG avoidance in the flatworm Schistosoma mansoni</atitle><jtitle>Journal of molecular evolution</jtitle><addtitle>J Mol Evol</addtitle><date>1994-01</date><risdate>1994</risdate><volume>38</volume><issue>1</issue><spage>36</spage><epage>40</epage><pages>36-40</pages><issn>0022-2844</issn><eissn>1432-1432</eissn><coden>JMEVAU</coden><abstract>We report the analysis of the biases of CpG, TpG, and CpA of all the DNA sequences data from the Trematode Schistosoma mansoni. 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subjects	Animals Base Composition Biological and medical sciences Dinucleoside Phosphates - genetics DNA - genetics DNA, Ribosomal - genetics Fundamental and applied biological sciences. Psychology Genes. Genome GENOMAS GENOME Introns METHYLATION METILACION Molecular and cellular biology Molecular genetics NUCLEOTIDE NUCLEOTIDOS Protein Biosynthesis Repetitive Sequences, Nucleic Acid SCHISTOSOMA MANSONI Schistosoma mansoni - genetics SECUENCIA NUCLEICA SEQUENCE NUCLEIQUE TECHNIQUE ANALYTIQUE TECNICAS ANALITICAS
title	Possible implications of CpG avoidance in the flatworm Schistosoma mansoni
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