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HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro
We investigated the effect of human immunodeficiency virus type 1 (HIV‐1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti‐CD3, the Fc receptor–mediated che...
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| Published in: | Journal of leukocyte biology 1994-04, Vol.55 (4), p.545-551 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 551 |
| container_issue | 4 |
| container_start_page | 545 |
| container_title | Journal of leukocyte biology |
| container_volume | 55 |
| creator | Dürrbaum-Landmann, I Kaltenhäuser, E Flad, H D Ernst, M |
| description | We investigated the effect of human immunodeficiency virus type 1 (HIV‐1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti‐CD3, the Fc receptor–mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the expression of the monocyte marker GD14 and major histocompatibility complex class I and II was not influenced. According to these phenotypic results, preincubation of monocytes with rec.gp120 depressed anti‐CD3 antibody‐induced T cell stimulation and Fc receptor‐mediated phagocytosis as determined by chemiluminescence. Interferon‐γ release of lymphocytes induced by purified protein derivative of tuberculin was enhanced by gp120. These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV‐1 infection in viva J. Leukoc. Biol. 55: 545–551; 1994. |
| doi_str_mv | 10.1002/jlb.55.4.545 |
| format | article |
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Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti‐CD3, the Fc receptor–mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the expression of the monocyte marker GD14 and major histocompatibility complex class I and II was not influenced. According to these phenotypic results, preincubation of monocytes with rec.gp120 depressed anti‐CD3 antibody‐induced T cell stimulation and Fc receptor‐mediated phagocytosis as determined by chemiluminescence. Interferon‐γ release of lymphocytes induced by purified protein derivative of tuberculin was enhanced by gp120. These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV‐1 infection in viva J. Leukoc. Biol. 55: 545–551; 1994.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1002/jlb.55.4.545</identifier><identifier>PMID: 8145026</identifier><identifier>CODEN: JLBIE7</identifier><language>eng</language><publisher>Bethesda, MD: Society for Leukocyte Biology</publisher><subject>AIDS/HIV ; antigen presentation ; Antigen Presentation - drug effects ; anti‐CD3 stimulation ; Biological and medical sciences ; CD4 and Fc receptors ; CD4 Antigens - analysis ; HIV Envelope Protein gp120 - pharmacology ; HIV Infections - immunology ; human immunodeficiency virus 1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; In Vitro Techniques ; Interleukin-6 - biosynthesis ; Luminescent Measurements ; Lymphocyte Activation - drug effects ; Medical sciences ; Monocytes - drug effects ; Monocytes - immunology ; phagocytosis ; Phenotype ; Receptors, Fc - analysis ; Tuberculin - immunology</subject><ispartof>Journal of leukocyte biology, 1994-04, Vol.55 (4), p.545-551</ispartof><rights>1994 Society for Leukocyte Biology</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4185-8fc44c95e4c3caa30358da8bd45038a460dacbfe54b9e149322dafa3ce8725af3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4103501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8145026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dürrbaum-Landmann, I</creatorcontrib><creatorcontrib>Kaltenhäuser, E</creatorcontrib><creatorcontrib>Flad, H D</creatorcontrib><creatorcontrib>Ernst, M</creatorcontrib><title>HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>We investigated the effect of human immunodeficiency virus type 1 (HIV‐1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti‐CD3, the Fc receptor–mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the expression of the monocyte marker GD14 and major histocompatibility complex class I and II was not influenced. According to these phenotypic results, preincubation of monocytes with rec.gp120 depressed anti‐CD3 antibody‐induced T cell stimulation and Fc receptor‐mediated phagocytosis as determined by chemiluminescence. Interferon‐γ release of lymphocytes induced by purified protein derivative of tuberculin was enhanced by gp120. These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV‐1 infection in viva J. Leukoc. Biol. 55: 545–551; 1994.</description><subject>AIDS/HIV</subject><subject>antigen presentation</subject><subject>Antigen Presentation - drug effects</subject><subject>anti‐CD3 stimulation</subject><subject>Biological and medical sciences</subject><subject>CD4 and Fc receptors</subject><subject>CD4 Antigens - analysis</subject><subject>HIV Envelope Protein gp120 - pharmacology</subject><subject>HIV Infections - immunology</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>In Vitro Techniques</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Luminescent Measurements</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Medical sciences</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>phagocytosis</subject><subject>Phenotype</subject><subject>Receptors, Fc - analysis</subject><subject>Tuberculin - immunology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFkEuP1DAQhC0EWoaFG1ekHIATGdqvPI6wYh9oJIQEXC3Hae945dghzmw0_x6jjOYIpz7UV93VRchrClsKwD4--G4r5VZspZBPyIa2vCl5VfOnZAO1oKUUAM_Ji5QeAICzCi7IRUOFBFZtyPfbu18lLTA8oo8jFuMUZ3ShuB8pg0Jbi2ZOxbjHEOdj1nXoC3sIZnYxFNEWQwzRHGdMRTY9unmKL8kzq33CV6d5SX5ef_lxdVvuvt3cXX3alUbQRpaNNUKYVqIw3GjNgcum103X52C80aKCXpvOohRdi1S0nLFeW80NNjWT2vJL8n7dmyP_PmCa1eCSQe91wHhIqq4Eq7io_wvSqqXQAsvghxU0U0xpQqvGyQ16OioK6m_VKletpFRC5aoz_ua099AN2J_hU7dZf3vSdTLa20kH49IZEzS_DDRjdMUW5_H4z5Pq6-4zrKffrZ69u98vbkKVBu19DsLUsizniH8AzZSiYQ</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Dürrbaum-Landmann, I</creator><creator>Kaltenhäuser, E</creator><creator>Flad, H D</creator><creator>Ernst, M</creator><general>Society for Leukocyte Biology</general><general>Federation of American Societies for Experimental Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199404</creationdate><title>HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro</title><author>Dürrbaum-Landmann, I ; Kaltenhäuser, E ; Flad, H D ; Ernst, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4185-8fc44c95e4c3caa30358da8bd45038a460dacbfe54b9e149322dafa3ce8725af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>AIDS/HIV</topic><topic>antigen presentation</topic><topic>Antigen Presentation - drug effects</topic><topic>anti‐CD3 stimulation</topic><topic>Biological and medical sciences</topic><topic>CD4 and Fc receptors</topic><topic>CD4 Antigens - analysis</topic><topic>HIV Envelope Protein gp120 - pharmacology</topic><topic>HIV Infections - immunology</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>In Vitro Techniques</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Luminescent Measurements</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Medical sciences</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - immunology</topic><topic>phagocytosis</topic><topic>Phenotype</topic><topic>Receptors, Fc - analysis</topic><topic>Tuberculin - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dürrbaum-Landmann, I</creatorcontrib><creatorcontrib>Kaltenhäuser, E</creatorcontrib><creatorcontrib>Flad, H D</creatorcontrib><creatorcontrib>Ernst, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dürrbaum-Landmann, I</au><au>Kaltenhäuser, E</au><au>Flad, H D</au><au>Ernst, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>1994-04</date><risdate>1994</risdate><volume>55</volume><issue>4</issue><spage>545</spage><epage>551</epage><pages>545-551</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><coden>JLBIE7</coden><abstract>We investigated the effect of human immunodeficiency virus type 1 (HIV‐1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti‐CD3, the Fc receptor–mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the expression of the monocyte marker GD14 and major histocompatibility complex class I and II was not influenced. According to these phenotypic results, preincubation of monocytes with rec.gp120 depressed anti‐CD3 antibody‐induced T cell stimulation and Fc receptor‐mediated phagocytosis as determined by chemiluminescence. Interferon‐γ release of lymphocytes induced by purified protein derivative of tuberculin was enhanced by gp120. These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV‐1 infection in viva J. Leukoc. 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| identifier | ISSN: 0741-5400 |
| ispartof | Journal of leukocyte biology, 1994-04, Vol.55 (4), p.545-551 |
| issn | 0741-5400 1938-3673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76426347 |
| source | Alma/SFX Local Collection |
| subjects | AIDS/HIV antigen presentation Antigen Presentation - drug effects anti‐CD3 stimulation Biological and medical sciences CD4 and Fc receptors CD4 Antigens - analysis HIV Envelope Protein gp120 - pharmacology HIV Infections - immunology human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology In Vitro Techniques Interleukin-6 - biosynthesis Luminescent Measurements Lymphocyte Activation - drug effects Medical sciences Monocytes - drug effects Monocytes - immunology phagocytosis Phenotype Receptors, Fc - analysis Tuberculin - immunology |
| title | HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro |
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