Bronchopulmonary dysplasia

Bronchopulmonary dysplasia is a chronic lung disease that affects premature babies and contributes to their morbidity and mortality. Improved survival of very immature infants has led to increased numbers of infants with this disorder. This increase puts a heavy burden on health resources since thes...

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Bibliographic Details
Published in:The Lancet (British edition) 2006-04, Vol.367 (9520), p.1421-1431
Main Authors: Kinsella, John P, Greenough, Anne, Abman, Steven H
Format: Article
Language:English
Subjects:
Antioxidants - therapeutic use
Biological and medical sciences
Birth weight
Bronchopulmonary Dysplasia - drug therapy
Bronchopulmonary Dysplasia - physiopathology
Bronchopulmonary Dysplasia - prevention & control
Corticoids
Epidemiology
General aspects
Humans
Infant
Infant mortality
Infant, Newborn
Infant, Premature
Infants
Life support systems
Longitudinal Studies
Medical sciences
Mortality
Neonates
Oxygen
Oxygen Inhalation Therapy
Pneumology
Premature birth
Prognosis
Pulmonary Circulation
Respiratory diseases
Respiratory system : syndromes and miscellaneous diseases
Studies
Superoxide Dismutase - therapeutic use
Ventilation
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Summary:Bronchopulmonary dysplasia is a chronic lung disease that affects premature babies and contributes to their morbidity and mortality. Improved survival of very immature infants has led to increased numbers of infants with this disorder. This increase puts a heavy burden on health resources since these infants need frequent re-admission to hospital in the first 2 years after birth and, even as adolescents, have lung-function abnormalities and persistent respiratory symptoms. Unlike the original description of the disease in 1967, premature infants can develop chronic oxygen dependency without severe, acute respiratory distress; this “new bronchopulmonary dysplasia” could be the result of impaired postnatal lung growth. Whether such infants subsequently have catch-up lung growth, especially if given corticosteroids postnatally, is unknown. No safe and effective preventive therapy has been identified, but promising new treatments directed either at reducing lung injury or improving lung growth are under study.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(06)68615-7