Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition

To enhance understanding of the biomechanical role of the intervertebral disc, the compressive properties and biochemical composition of nondegenerate samples of anulus fibrosus were determined as a function of radial position, region, and level. Because of the large swelling propensity of this tiss...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1994-01, Vol.19 (2), p.212-221
Main Authors: BEST, B. A, GUILAK, F, SETTON, L. A, WENBO ZHU, FATEMEH SAED-NEJAD, RATCLIFFE, A, WEIDENBAUM, M, MOW, V. C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomechanical Phenomena
Elasticity
Fundamental and applied biological sciences. Psychology
Glycosaminoglycans - metabolism
Humans
Hydroxyproline - metabolism
Intervertebral Disc - metabolism
Intervertebral Disc - physiology
Middle Aged
Permeability
Pressure
Skeleton and joints
Stress, Mechanical
Vertebrates: osteoarticular system, musculoskeletal system
Water - metabolism
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Summary:To enhance understanding of the biomechanical role of the intervertebral disc, the compressive properties and biochemical composition of nondegenerate samples of anulus fibrosus were determined as a function of radial position, region, and level. Because of the large swelling propensity of this tissue, a method was developed to test excised specimens while maintaining their in situ geometry and hydration. Using an analysis based on linear biphasic theory, the compressive modulus, hydraulic permeability, and isometric swelling pressure of the anulus fibrosus were determined and correlated with the tissue composition. The findings indicate that the anulus fibrosus is inhomogeneous, with regional and radial variations in both material properties and biochemical composition. The results of this study suggest that both structural and compositional factors may determine the mechanical behavior.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-199401001-00017