Matrix Modification for Furnace Atomic Absorption Spectrometric Determination of Arsenic in Whole Human Blood

A method for the determination of arsenic in whole human blood is presented. To decrease the matrix effects from this complex sample, the blood was prediluted with a matrix modifier solution. The modifier solution contained a surfactant, Triton X-100, which homogenized the sample and allowed accurat...

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Bibliographic Details
Published in:Journal of analytical toxicology 1985-09, Vol.9 (5), p.213-216
Main Authors: Eaton, David K., McCutcheon, John R.
Format: Article
Language:English
Subjects:
Arsenic
Arsenic - blood
Biological and medical sciences
Blood
Chemical and industrial products toxicology. Toxic occupational diseases
Forensic science
Humans
Medical sciences
Metals and various inorganic compounds
Nickel
Nitrate
Spectrophotometry, Atomic - methods
Surfactants
Temperature
Temperature effects
Toxicology
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Summary:A method for the determination of arsenic in whole human blood is presented. To decrease the matrix effects from this complex sample, the blood was prediluted with a matrix modifier solution. The modifier solution contained a surfactant, Triton X-100, which homogenized the sample and allowed accurate pipetting by an autosempler. The modifier also contained nickel nitrate which stabilized the arsenic and allowed ash temperatures of 1400° without loss of the arsenic. The method exhibited a sensitivity of 5µg/L (concentration/1% absorption) which was sufficient for the forensic evaluation of elevated arsenic levels in the blood.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/9.5.213