Clinical Management of Intra-Amniotic Infection and Chorioamnionitis: A Review of the Literature

Intra-amniotic infection (IAI), or chorioamnionitis, complicates up to 10% of all pregnancies and up to 2% of labors at term. There is a significant risk of complications for the mother and the neonate following IAI, including sepsis and pneumonia. In addition, there is a correlation between IAI and...

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Bibliographic Details
Published in:Journal of midwifery & women's health 2008-05, Vol.53 (3), p.227-235
Main Author: Fahey, Jenifer O.
Format: Article
Language:English
Subjects:
Amniocentesis
Anti-Bacterial Agents - administration & dosage
Cerebral palsy
Cerebral Palsy - etiology
Cerebral Palsy - prevention & control
Childbirth & labor
chorioamnionitis
Chorioamnionitis - diagnosis
Chorioamnionitis - microbiology
Chorioamnionitis - therapy
Clinical management
Female
fetal inflammatory response
Fetal Membranes, Premature Rupture - therapy
Fetuses
Gynecology
Humans
Infant, Newborn
Infection
Infectious diseases
Inflammation
intra-amniotic
intrauterine
Nursing
Obstetric Labor, Premature - etiology
Obstetric Labor, Premature - prevention & control
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - microbiology
Pregnancy Complications, Infectious - therapy
premature rupture of membranes
Risk Factors
Vaginosis, Bacterial - diagnosis
Vaginosis, Bacterial - drug therapy
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Summary:Intra-amniotic infection (IAI), or chorioamnionitis, complicates up to 10% of all pregnancies and up to 2% of labors at term. There is a significant risk of complications for the mother and the neonate following IAI, including sepsis and pneumonia. In addition, there is a correlation between IAI and premature rupture of membranes, preterm premature rupture of membranes, preterm labor, and preterm birth. Research in the last decade has also revealed a complex and significant association between IAI and cerebral palsy and other central nervous system damage in both the preterm and term fetus. Timely diagnosis and treatment of IAI can significantly reduce the risk of both maternal and neonatal complications.
ISSN:1526-9523
1542-2011
DOI:10.1016/j.jmwh.2008.01.001