Coffee consumption and risk of breast cancer: a metaanalysis

Objective This metaanalysis was conducted to assess the association between coffee consumption and breast cancer risk. Study Design Relevant studies were identified by searching Medline (1966-May 2008) and the reference lists of retrieved articles. The summary relative risk (RR) with 95% confidence...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2009-03, Vol.200 (3), p.290.e1-290.e9
Main Authors: Tang, Naping, MD, Zhou, Bo, MD, Wang, Bin, PhD, Yu, Rongbin, PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
breast cancer
Breast Neoplasms - epidemiology
Caffeine - adverse effects
Case-Control Studies
Central Nervous System Stimulants - adverse effects
Coffee - adverse effects
coffee consumption
Cohort Studies
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
metaanalysis
Obstetrics and Gynecology
Risk Factors
Tumors
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Summary:Objective This metaanalysis was conducted to assess the association between coffee consumption and breast cancer risk. Study Design Relevant studies were identified by searching Medline (1966-May 2008) and the reference lists of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated using a random-effects model. Results Nine cohort and 9 case-control studies met the inclusion criteria. The combined RR showed a borderline significant influence of highest coffee consumption (RR, 0.95; 95% CI, 0.90-1.00) or an increment of 2 cups/day of coffee consumption (RR, 0.98; 95% CI, 0.96-1.00) on the risk of breast cancer. In stratified analysis, borderline significant associations were observed among cohort and case-control studies and studies conducted in Europe and the United States. However, no significant association was noted among studies conducted in Asia. Conclusion Our findings suggest a possible influence of high coffee consumption or an increased coffee consumption on the risk of breast cancer.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2008.10.019