Central effects of baclofen on the L-dopa induced hyperactive urinary bladder of the rat

Cystometric recordings were performed in pentobarbitone anaesthetized rats and the effects of baclofen on urinary bladder function were evaluated as their influence on bladder hyperactivity induced by 1-dihydroxyphenylalanine (L-dopa) after peripheral decarboxylase inhibition. The bladder response w...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1985-09, Vol.330 (3), p.175-178
Main Authors: SILLEN, U, PERSSON, B, RUBENSON, A
Format: Article
Language:English
Subjects:
Animals
Aromatic Amino Acid Decarboxylase Inhibitors
Baclofen - administration & dosage
Baclofen - pharmacology
Bicuculline - pharmacology
Biological and medical sciences
gamma-Aminobutyric Acid - physiology
Glutamates - pharmacology
Glutamic Acid
Injections, Intraventricular
Levodopa - pharmacology
Male
Medical sciences
Miscellaneous
Naloxone - pharmacology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Substance P - pharmacology
Urinary Bladder - drug effects
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Summary:Cystometric recordings were performed in pentobarbitone anaesthetized rats and the effects of baclofen on urinary bladder function were evaluated as their influence on bladder hyperactivity induced by 1-dihydroxyphenylalanine (L-dopa) after peripheral decarboxylase inhibition. The bladder response was inhibited by intracerebroventricularly (i.c.v., 4th ventricle, 0.1 microgram) as well as by systemically administered (10 mg/kg i.v.) baclofen. Intravenous naloxone but not i.v. bicuculline i.c.v. substance P or i.c.v. glutamate antagonized the inhibitory actions of i.c.v. or/and i.v. baclofen. It is suggested that baclofen depresses the hyperactive bladder by a central action that is unrelated to bicuculline sensitive gamma aminobutyric acid mechanisms, substance P or glutamate neurotransmission but that is possibly related to interference with opioid mechanisms.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00572430