Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection

To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfectio...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-03, Vol.169 (3), p.628-632
Main Authors: Kashala, Oscar, Mubikayi, Luamba, Kayembe, Kalambayi, Mukeba, Prudence, Essex, Max
Format: Article
Language:English
Subjects:
Adult
Africa, Central - epidemiology
AIDS
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - microbiology
AIDS/HIV
Antibodies
Antigens
Biological and medical sciences
Biomarkers
Concise Communications
Developed countries
Female
Hepatitis antigens
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B - microbiology
Hepatitis B Surface Antigens - biosynthesis
Hepatitis B virus
Hepatitis B virus - physiology
Hepatocellular carcinoma
HIV
HIV infections
HIV-1
human immunodeficiency virus 1
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Pregnancy
Prevalence
Protein Precursors - biosynthesis
Tropical medicine
Viral diseases
Viral hepatitis
Virus Activation
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Summary:To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence of HBV infection and HBV surface antigen (HBsAg) was similar for HIV-positive and -negative persons. AIDS patients were more likely to be HBsAg positive and have markers of viral replication. Unlike pre-surface (pre-s) 1 antigen (Ag), which did not differ significantly with respect to HIV infection, pre-s2Ag was more common among HIV-positive persons than among HIV-negative ones and was more common among AIDS patients than among HIV-positive asymptomatic carriers. HIV-positive persons had more markers consistent with HBV reactivation and lower levels of antibody to HBsAg.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.3.628