Therapeutic advantages of monitoring plasma concentrations of perphenazine in clinical practice

Two hundred and twenty-eight acute paranoid psychotic in-patients received continuous treatment with perphenazine for a period of at least 5 weeks, before blood samples were taken to determine perphenazine plasma levels and conclusions regarding therapeutic efficacy and motor side effects. Patients...

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Bibliographic Details
Published in:Psychopharmacologia 1985-01, Vol.87 (1), p.16-19
Main Authors: HANSEN, L. B, LARSEN, N.-E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Female
Humans
Male
Medical sciences
Middle Aged
Monitoring, Physiologic
Neuropharmacology
Paranoid Disorders - drug therapy
Perphenazine - blood
Perphenazine - therapeutic use
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Schizophrenia - drug therapy
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Summary:Two hundred and twenty-eight acute paranoid psychotic in-patients received continuous treatment with perphenazine for a period of at least 5 weeks, before blood samples were taken to determine perphenazine plasma levels and conclusions regarding therapeutic efficacy and motor side effects. Patients with plasma concentrations within the range of 2-6 nmol/l showed an excellent antipsychotic response, concomitantly with a low incidence of extrapyramidal side effects. However, patients with plasma levels below or above this range either demonstrated a poor therapeutic response or a high degree of side effects respectively. The results indicate that with increasing age significantly lower doses of perphenazine are required to ensure an optimal clinical response. No difference, however, was seen between sexes with regard to dose response.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00431770