Dynamic pathways of selenium metabolism and excretion in mice under different selenium nutritional statuses

The selenoprotein, cellular glutathione peroxidase (cGPx), has an important role in protecting organisms from oxidative damage through reducing levels of harmful peroxides. The liver and kidney in particular, have important roles in selenium (Se) metabolism and Se is excreted predominantly in urine...

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Bibliographic Details
Published in:Metallomics 2010-01, Vol.2 (2), p.126-132
Main Authors: Suzuki, Yoshinari, Hashiura, Yoshiteru, Matsumura, Kentaro, Matsukawa, Takahisa, Shinohara, Atsuko, Furuta, Naoki
Format: Article
Language:English
Subjects:
Animals
Carbohydrate Metabolism
Chromatography, Gel
Chromatography, High Pressure Liquid
Glutathione Peroxidase - metabolism
Hepatocytes - chemistry
Hepatocytes - metabolism
Mass Spectrometry
Mice
Selenium - administration & dosage
Selenium - deficiency
Selenium - metabolism
Selenium - pharmacokinetics
Selenium Compounds - metabolism
Selenium Compounds - pharmacokinetics
Tissue Distribution
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Summary:The selenoprotein, cellular glutathione peroxidase (cGPx), has an important role in protecting organisms from oxidative damage through reducing levels of harmful peroxides. The liver and kidney in particular, have important roles in selenium (Se) metabolism and Se is excreted predominantly in urine and feces. In order to characterize the dynamics of these pathways we have measured the time-dependent changes in the quantities of hepatic, renal, urinary, and fecal Se species in mice fed Se-adequate and Se-deficient diets after injection of (82)Se-enriched selenite. Exogenous (82)Se was transformed to cGPx in both the liver and kidney within 1 h after injection and the synthesis of cGPx decreased 1 to 6 h and continued at a constant level from 6 to 72 h after injection. The total amount of Se associated with cGPx in mice fed Se-deficient diets was found to be less than in mice fed Se-adequate diets. This finding indicated that cGPx synthesis was suppressed under Se-deficient conditions and did not recover with selenite injection. Excess Se was associated with selenosugar in liver and transported to the kidney within 1 h after injection, and then excreted in urine and feces within 6 h after injection. Any excess amount of Se was excreted mainly as a selenosugar in urine.
ISSN:1756-5901
1756-591X
DOI:10.1039/b915816b