Primary Acute Simian Immunodeficiency Virus Infection of Intestinal Lymphoid Tissue Is Associated with Gastrointestinal Dysfunction

Human immunodeficiency virus (HIV)-associated intestinal abnormalities can occur before immunodeficiency or infection with opportunistic enteropathogens. Rhesus macaques infected with simian immunodeficiency virus (SIV) develop an AIDS-like illness that frequently includes enteropathy. The developme...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1994-05, Vol.169 (5), p.1116-1120
Main Authors: Heise, Carla, Miller, Christopher J., Lackner, Andrew, Dandekar, Satya
Format: Article
Language:English
Subjects:
Acute Disease
AIDS/HIV
Animals
Antibodies
Biological and medical sciences
Concise Communications
Digestive System - microbiology
Digestive System - pathology
Digestive System - physiopathology
Dosage
Enzyme linked immunosorbent assay
Female
H1N1 subtype influenza A virus
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infants
Infections
Influenza vaccines
Intestinal Absorption
Lymphoid Tissue - microbiology
Macaca mulatta
Macrophages - microbiology
Male
Medical sciences
primates
Simian Acquired Immunodeficiency Syndrome - pathology
Simian Acquired Immunodeficiency Syndrome - physiopathology
simian immunodeficiency virus
T-Lymphocytes - microbiology
Transcriptional regulatory elements
Vaccination
Viruses
Xylose - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human immunodeficiency virus (HIV)-associated intestinal abnormalities can occur before immunodeficiency or infection with opportunistic enteropathogens. Rhesus macaques infected with simian immunodeficiency virus (SIV) develop an AIDS-like illness that frequently includes enteropathy. The development of enteropathy and its association with SIV infection in the intestinal tract was examined. By 1 week after infection, SIV-infected macrophages and T lymphocytes were detected in gut-associated lymphoid tissue. In contrast to findings in the asymptomatic stage, SIV-infected macrophages were numerous in primary and terminal stages of infection. An acute enteropathy syndrome was observed in the primary acute stage of infection. Functional abnormalities of absorptive epithelium, indicated by d-xylose malabsorption and decreased sucrase activity, occurred before the onset of diarrhea or opportunistic enteric infections. These findings indicate that macrophages and T cells in the intestinal tract are early targets of SIV infection and may playa critical role in the developmentof SIV-associated intestinal dysfunction.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/169.5.1116