Oxygen demand of calcium-tolerant adult cardiac myocytes

Isolated Ca2+-tolerant myocytes are mechanically at rest. Therefore, minimal oxygen demands should be expected. If oxygen consumption is measured without mechanical agitation of the cells, consumption rates comparable to those of the arrested myocardium are measured. In the current literature, much...

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Bibliographic Details
Published in:Basic research in cardiology 1985, Vol.80 Suppl 2, p.71-74
Main Authors: Spieckermann, P G, Piper, H M
Format: Article
Language:English
Subjects:
Aging
Animals
Calcium - metabolism
Calcium - pharmacology
Cell Separation
Myocardium - cytology
Myocardium - metabolism
Oxygen Consumption - drug effects
Rats
Rats, Inbred Strains
Temperature
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Summary:Isolated Ca2+-tolerant myocytes are mechanically at rest. Therefore, minimal oxygen demands should be expected. If oxygen consumption is measured without mechanical agitation of the cells, consumption rates comparable to those of the arrested myocardium are measured. In the current literature, much higher values are usually reported. It is suggested that these are due to mechanical stimulation of the cells in stirred suspensions.
ISSN:0300-8428