Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein

We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP). Using a cell line that contains high levels of estrogen receptors, we have found that treatment with physiological concentrations of 17 beta-estradiol is associated with accumulat...

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Bibliographic Details
Published in:The Journal of biological chemistry 1994-05, Vol.269 (18), p.13065-13068
Main Authors: JAFFE, A. B, TORAN-ALLERAND, D, GREENGARD, P, GANDY, S. E
Format: Article
Language:English
Subjects:
Amyloid beta-Protein Precursor - metabolism
Biological and medical sciences
Culture Media, Conditioned
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Estradiol - physiology
Humans
Medical sciences
Neurology
Tumor Cells, Cultured
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Summary:We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP). Using a cell line that contains high levels of estrogen receptors, we have found that treatment with physiological concentrations of 17 beta-estradiol is associated with accumulation in the conditioned medium of an amino-terminal cleavage product of APP (soluble APP or protease nexin-2), indicative of non-amyloidogenic processing. There were no obvious changes in the levels of intracellular immature or mature APP holoproteins, suggesting that estrogen may increase the secretory metabolism of APP.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(17)36796-0