Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease : prevalence, plasma cholesterol levels and cerebrovascular change

The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented p...

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Published in:European archives of psychiatry and clinical neuroscience 1994-02, Vol.243 (5), p.291-292
Main Authors: CZECH, C, FÖRSTL, H, HENTSCHEL, F, MÖNNING, U, BESTHORN, C, GEIGER-KABISCH, C, SATTEL, H, MASTERS, C, BEYREUTHER, K
Format: Article
Language:English
Subjects:
Aged
Alleles
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Apolipoprotein E4
Apolipoproteins E - genetics
Biological and medical sciences
Brain - pathology
Cerebral Infarction - diagnosis
Cerebral Infarction - genetics
Cerebral Infarction - pathology
Cholesterol - blood
Chromosomes, Human, Pair 19
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Genetic Carrier Screening
Genotype
Humans
Male
Medical sciences
Middle Aged
Neurology
Risk Factors
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Summary:The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented patients homozygotic for Apo E-4, but no significant increases of glucose, triglycerides and thyroxine or of leuko-araiosis and brain infarcts were verified in this preliminary study.
ISSN:0940-1334
1433-8491
DOI:10.1007/BF02191587