In-vitro activity of five β-lactam/β-lactamase inhibitor combinations against consecutive isolates of the Enterobacteriaceae and Pseudomonas aeruginosa

Susceptibility tests were performed on 2402 of consecutive isolates of Enterobacteriaceae and 254 strains of Pseudomonas aeruginosa in five separate medical centres. Five β-lactams were evaluated with and without a β-lactamase inhibitor. The effect of different inhibitors was species specific and th...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1994-02, Vol.33 (2), p.223-230
Main Authors: McLaughlin, J. C., Barry, A. L., Fuchs, P. C., Gerlach, E. H., Hardy, D. J., Pfaller, M. A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamase Inhibitors
beta-Lactams
Biological and medical sciences
Drug Therapy, Combination - pharmacology
Enterobacteriaceae - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pseudomonas aeruginosa - drug effects
Species Specificity
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Summary:Susceptibility tests were performed on 2402 of consecutive isolates of Enterobacteriaceae and 254 strains of Pseudomonas aeruginosa in five separate medical centres. Five β-lactams were evaluated with and without a β-lactamase inhibitor. The effect of different inhibitors was species specific and the rank order of decreasing efficacy against all enteric bacilli was: cefoperazone-sulbactam > piperacillin-tazobactam > cefoperazone > ticarcillin-clavulanic acid > piperacillin > co-amoxiclav > ampicillin-sulbactam > ticarcillin > ampicillin > amoxycillin.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/33.2.223