Disproportionate ileal digestion on canine food consumption : a possible model for satiety in pancreatic insufficiency

In animals, ileal sensors of nutrients signal satiety more potently than similar sensors in jejunum. We postulated that inadequate food intake and weight loss in human pancreatic insufficiency might arise by the displacement of digestion to ileum, where excessive release of digestive products would...

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Bibliographic Details
Published in:Digestive diseases and sciences 1994-05, Vol.39 (5), p.1014-1024
Main Authors: MEYER, J. H, ELASHOFF, J. D, DOTY, J. E, GU, Y. G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Digestion
Dogs
Eating - physiology
Exocrine Pancreatic Insufficiency - physiopathology
Female
Gastric Emptying
Gastroenterology. Liver. Pancreas. Abdomen
Ileum - physiology
Ileum - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
Satiation - physiology
Weight Loss
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Summary:In animals, ileal sensors of nutrients signal satiety more potently than similar sensors in jejunum. We postulated that inadequate food intake and weight loss in human pancreatic insufficiency might arise by the displacement of digestion to ileum, where excessive release of digestive products would enhance satiety. To test this idea, we studied dogs prepared with pancreatic fistulas, which allowed reversible switching of pancreatic juice from entry at duodenum to entry at mid-small intestine. Dogs were studied in a crossover design over successive eight-day periods. Food consumption and body weight were measured while the dogs had continuous access to food. Diversion of pancreatic juice to mid-intestine significantly (P < 0.01) depressed food intake by an average of 28%. Diversion also significantly (P < 0.01) reduced body weight. The findings support the idea that insufficient food intake in human pancreatic insufficiency may result from stimulation of ileal satiety mechanisms.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF02087553