Quantitation of gentamicin sulfate in injectable solutions by capillary electrophoresis

The results presented in this communication establish the use of capillary electrophoresis as a tool in the analysis of injectable solutions containing the antibiotic complex gentamicin sulfate. The utilization of a borate buffer leads to the separation of the individual components and their visuali...

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Bibliographic Details
Published in:Journal of Chromatography A 1994-03, Vol.663 (2), p.259-263
Main Authors: Flurer, Cheryl L., Wolnik, Karen A.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Electrophoresis
General pharmacology
Gentamicins - analysis
Hydrogen-Ion Concentration
Indicators and Reagents
Medical sciences
Pharmacology. Drug treatments
Reference Standards
Solutions
Spectrophotometry, Ultraviolet
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Summary:The results presented in this communication establish the use of capillary electrophoresis as a tool in the analysis of injectable solutions containing the antibiotic complex gentamicin sulfate. The utilization of a borate buffer leads to the separation of the individual components and their visualization by direct UV detection. This rapid and straightforward procedure yields qualitative and quantitative information simultaneously, and could be utilized as an alternative to the multiple assays required by current US Pharmacopeia protocols.
ISSN:0021-9673
DOI:10.1016/0021-9673(94)85253-7